Porous polyurethane film fabricated via the breath figure approach for sustained drug release
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent under 55-80% relative humidity. The porous PU films were prepared within various pore structures and sizes, which were adjustable, depending on the fabrication conditions. The humidity and exposure time were examined as variable parameters affecting the surface morphology, wettability, and cytotoxicity. Atorvastatin calcium, a hyperlipidemic agent, was loaded into the porous films during the casting process, and the drug-loading and drug-releasing behaviors of the porous PU membranes were evaluated. Approximately 60-80% of the drug was released in 14 days. The films exhibited sustained drug-release performances because of the hydrophobicity and nonbiodegradable nature of PU for perivascular drug administration.
Description
Bozdoğan, Betül (Aksaray Author)
Keywords
Drug-Delivery Systems, Polyurethane, Porous Materials, Self-Assembly
Journal or Series
Journal of Applied Polymer Science
WoS Q Value
N/A
Scopus Q Value
Q2
Volume
136
Issue
25
