Haplotype analysis of non-HLA immunogenetic loci in Turkish and worldwide populations

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dc.authoridPolimanti, Renato -- 0000-0003-0745-6046; Ozgul, Riza Koksal -- 0000-0002-0283-635X
dc.contributor.authorKaraca, Şefayet
dc.contributor.authorKaraca, Mehmet
dc.contributor.authorCivelek, Ersoy
dc.contributor.authorÖzgül, Rıza Köksal
dc.contributor.authorŞekerel, Bülent Enis
dc.contributor.authorPolimanti, Renato
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:17Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:17Z
dc.date.issued2016
dc.departmentSağlık Bilimleri Fakültesi
dc.description.abstractImmunogenes (i.e., genes related to the immune system and its functions) are involved in the predisposition to numerous traits and their variation contributes to the phenotypic variability observed among human groups. Turkish population presents particular genetic features since its genetic pool is an admixture of European, Middle-Eastern, and Central Asian ancestries. Here, we analyzed the haplotype structure of four immunogenetic loci (i.e., ADAM33; IL13-IL4; IL4R; MS4A2) in 482 subjects from five different regions of Turkey. Genotyping was performed using KASP technology. Turkish data were compared with the haplotype information available from the 1000 Genomes Project Phase 3 (26 human populations from 5 ancestry groups). We did not observe significant differences among Turkish groups. Comparing other ancestries, we identified haplotype similarity of Turkish subjects with European populations in IL13-1L4, IL4R, and ADAM33 loci; and with central Asians in MS4A2 region. Considering loci displaying Turkish-European haplotype similarity (i.e., IL13-1L4, IL4R, and ADAM33), we observed differences between Turkish subjects and northern/western Europeans. Conversely, no significant difference was determined in MS4A2 between Turkish and central Asian populations. Finally, we assessed the haplotypes responsible for the differences between Turkish and European samples and the potential functional effects on the immunogenetic loci investigated. (C) 2016 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [SBAG-2135025]
dc.description.sponsorshipThis study was supported by a grant (SBAG-2135025) from the Scientific and Technological Research Council of Turkey (TUBITAK). We are indebted to the field workers, those who collaborated in the participating centers, and all the parents and school staff who assisted in the surveys. The authors declare that they have no conflict of interest.
dc.identifier.doi10.1016/j.gene.2016.04.050
dc.identifier.endpage136en_US
dc.identifier.issn0378-1119
dc.identifier.issn1879-0038
dc.identifier.issue2en_US
dc.identifier.pmid27129937
dc.identifier.scopusqualityQ2
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.1016/j.gene.2016.04.050
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6016
dc.identifier.volume587en_US
dc.identifier.wosWOS:000377827600003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofGENE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGenetic Diversity
dc.subjectAdmixture
dc.subjectTurkish Population
dc.subjectImmunogenetics
dc.titleHaplotype analysis of non-HLA immunogenetic loci in Turkish and worldwide populations
dc.typeArticle

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