Norsquaraine endowed with anticancer and antibacterial activities

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dc.contributor.authorBoran Gülen, Rukiye
dc.contributor.authorSonkaya, Ömer
dc.contributor.authorErkan, Dilek Sadife
dc.contributor.authorToksoy, Alihan
dc.contributor.authorAlgı, Melek Pamuk
dc.contributor.authorAlgı, Fatih
dc.date.accessioned2023-01-11T05:44:46Z
dc.date.available2023-01-11T05:44:46Z
dc.date.issued2022
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractPhotodynamic therapy (PDT) is a method for the treatment of cancer. Furthermore, PDT can also be used for the eradication of bacteria. The photo-sensitizing drug, a.k.a photosensitizer, is critical for the success of PDT. Although norsquaraines are analogs of squaraine dyes, they are overlooked as photosensitizers. Methods: In this work, synthesis, characterization, bioimaging and in vitro PDT applications of a new norsquaraine dye 1 were described. We also prepared nanoparticles from norsquaraine 1 and Pluronic F127 to obtain 1@F127. Results: Norsquaraine 1 boosted the generation of reactive oxygen species over a wide range of pH (pH 8.0, 7.0, 6.0, and 2.2.). Furthermore, 1 was internalized by epidermoid laryngeal carcinoma Hep-2 (Hep-2) cells and used for fluorescence imaging. Remarkably, norsquaraine 1 destroyed most of the cancer cells (ca. 77% to 89%) after illumination with red light. Most strikingly, 1 successfully inhibited the growth of Methicillin-resistant Staphylococcus aureus (MRSA) upon illumination. Last but not least, photodynamic sterilization of tomato juice, an acidic beverage, was feasible using 1 as a photo sterilizer. Nano formulation of 1 with Pluronic F127 provided 1@F127 nanoparticles. It is lucid that 1@F127 nanoparticles permeate into Hep-2 cells and boost the generation of ROS upon illumination. Conclusion: Norsquaraine 1 shows superior features as a photosensitizer pertinent to PDT in a wide range of pH. This norsquaraine is endowed with anticancer and antibacterial activities. Which should be further evaluated.
dc.identifier.doi10.1016/j.pdpdt.2022.103110
dc.identifier.endpage-en_US
dc.identifier.issn1572-1000
dc.identifier.issue-en_US
dc.identifier.pmid36070851
dc.identifier.scopusqualityQ1
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1016/j.pdpdt.2022.103110
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9861
dc.identifier.volume40en_US
dc.identifier.wosWOS:000874612400007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntimicrobial Photodynamic Therapy
dc.subjectBioimaging
dc.subjectCancer
dc.subjectMethicillin-resistant Staphylococcus Aureus
dc.subjectNorsquaraine
dc.subjectPhotosensitizer
dc.titleNorsquaraine endowed with anticancer and antibacterial activities
dc.typeArticle

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