Protective effect of astaxanthin and metformin in the liver of rats in which the polycystic ovary syndrome model was formed by giving letrozole

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dc.contributor.authorTaştan, Tu?ba Bal
dc.contributor.authorAkaras, Nurhan
dc.contributor.authorDemir, Özlem
dc.contributor.authorUgan, Rüstem Anıl
dc.date.accessioned2023-10-02T12:29:11Z
dc.date.available2023-10-02T12:29:11Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractIn this study, the effects of astaxanthin on liver tissue in rats with polycystic ovary syndrome (PCOS) were evaluated. Materials and Methods: Fifty-four Spraque-Dawley rats were divided into 9 groups: Groups: Control, PCOS, PCOS+Metformin (Met), PCOS+ Astaxanthin (ASX)10, PCOS+ASX20, PCOS+ASX40, PCOS+Met+ASX10, PCOS+Met+ASX20, and PCOS+Met+ASX40. PCOS was induced in female rats by oral administration of letrozole (1 mg/kg) for 21 days. Rats were treated with ASX (10 mg/kg), ASX (20 mg/kg), ASX (40 mg/kg), and metformin (20 mg/kg) for 7 days after PCOS induction. At the end of the experiment, malondialdehyde (MDA) and superoxide dismutase (SOD) levels were measured in the liver tissue. The liver was stained with hematoxylin/eosin for histological examination. Additionally, NF-kB and caspase 3 were analyzed immunohistochemically. Results: A remarkable abnormality was observed in the biochemical and histological parameters in the liver tissue of the PCOS model rats. Astaxanthin dose-dependently normalized the MDA level. Additionally, astaxanthin showed a protective effect by increasing the SOD level and increasing its antioxidant activities. We observed that administration of astaxanthin in addition to metformin applied in the standard was more effective. Caspase 3 and NF-kB immune positivity was lower in the groups given astaxanthin compared with PCOS. Histologically, it was observed that astaxanthin improved the deteriorated liver morphology in the letrozole-induced PCOS group. Conclusion: According to our results, it was observed that astaxanthin had antioxidant, anti-inflammatory and anti-apoptotic effects on PCOS in the treatment groups. Therefore, it was concluded that astaxanthin may have a protective effect against PCOS side effects.
dc.identifier.doi10.22038/IJBMS.2023.68032.14872
dc.identifier.endpage694en_US
dc.identifier.issn2008-3866
dc.identifier.issue6en_US
dc.identifier.pmid37275752
dc.identifier.scopusqualityQ2
dc.identifier.startpage688en_US
dc.identifier.urihttps:/dx.doi.org10.22038/IJBMS.2023.68032.14872
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11038
dc.identifier.volume26en_US
dc.identifier.wosWOS:000988782100010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMashhad University of Medical Sciences
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAstaxanthine
dc.subjectLiver
dc.subjectMetformin
dc.subjectOxidative stress
dc.subjectPolycystic Ovary Syndrome
dc.subjectRat
dc.titleProtective effect of astaxanthin and metformin in the liver of rats in which the polycystic ovary syndrome model was formed by giving letrozole
dc.typeArticle

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