Evaluation of boron’s adjuvant activity in inactive bacterin vaccines using the mice model

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dc.contributor.authorSayın, Zafer
dc.contributor.authorUslu, Ali
dc.contributor.authorErganiş, Osman
dc.contributor.authorBaşo?lu, Abdullah
dc.contributor.authorÖzdemir, Özgür
dc.contributor.authorSakmanoğlu, Aslı
dc.contributor.authorUçan, Uçkun Sait
dc.contributor.authorAras, Zeki
dc.date.accessioned2021-02-03T11:11:40Z
dc.date.available2021-02-03T11:11:40Z
dc.date.issued2021
dc.departmentVeteriner Fakültesi
dc.descriptionAras, Zeki ( Aksaray, Yazar )
dc.description.abstractVaccination is the most effective, reliable, and economical way of preventing or reducing the effect of infectious diseases. When preparing inactive vaccines, a range of additives called adjuvants are necessary to enhance the magnitude of the immune response. Boron has a wide range of industrial and medical applications, and its positive effects on distinct functions have been described in plants, humans, and animals. However, no studies exist about the possible adjuvant activities of boron compounds in vaccines. Hence, in this study, the potential adjuvant effect of boric acid was explored and compared with common veterinary adjuvants in a mice model. Staphylococcus aureus (S. aureus) used as vaccine antigen was isolated from dairy cows with bovine mastitis. Vaccines adjuvanted with boric acid, aluminum hydroxide, Montanide ISA 50 and ISA 206, and Montanide + boric acid combinations were prepared. The efficacy of vaccines was evaluated according to local reactions at the injection site, C-reactive protein, total Ig G, total Ig M, and anti-S. aureus antibody levels in mice. Boric acid reduced local inflammatory reactions induced by the Montanide adjuvants. Moreover, mice vaccinated with boric acid-adjuvanted vaccine had higher levels of anti-S. aureus antibody than those in the controls (P < 0.05) and were similar to the levels found in mice sensitized with aluminum hydroxide. Total Ig G and Ig M results were, however, unsuitable for the assessment of adjuvant activity for this study. In conclusion, this study revealed that boric acid has an adjuvant potential in inactive bacterin vaccines, but further target animal studies are needed.
dc.identifier.doi10.1007/s12011-020-02233-5
dc.identifier.endpage1043en_US
dc.identifier.issn0163-4984
dc.identifier.issue3en_US
dc.identifier.pmid32557105
dc.identifier.scopusqualityQ1
dc.identifier.startpage1037en_US
dc.identifier.urihttps:/dx.doi.org/10.1007/s12011-020-02233-5
dc.identifier.urihttps://hdl.handle.net/20.500.12451/7717
dc.identifier.volume199en_US
dc.identifier.wosWOS:000541089800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAdjuvant
dc.subjectAluminum Hydroxide
dc.subjectBoric Acid
dc.subjectMontanide ISA 206
dc.subjectMontanide ISA 50
dc.subjectVaccine
dc.titleEvaluation of boron’s adjuvant activity in inactive bacterin vaccines using the mice model
dc.typeArticle

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