Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study

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dc.contributor.authorÖzgen, Merih
dc.contributor.authorCoşan, Didem Turgut
dc.contributor.authorDoğaner, Fulya
dc.contributor.authorSoyocak, Ahu
dc.contributor.authorArmağan, Onur
dc.contributor.authorKuzgun, Selen
dc.contributor.authorAydoğan, Ayşe Merve
dc.contributor.authorGüneş, Hasan Veysi
dc.contributor.authorDeğirmenci, İrfan
dc.contributor.authorMutlu, Fezan
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:16:40Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:16:40Z
dc.date.issued2019
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractOBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. RESULT: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.
dc.description.sponsorshipResearch Foundation of Eskisehir Osmangazi University Turkey [201211D08]
dc.description.sponsorshipThis study was supported by the Research Foundation of Eskisehir Osmangazi University Turkey (Project No: 201211D08). No potential conflict of interest was reported.
dc.identifier.doi10.6061/clinics/2019/e739
dc.identifier.issn1807-5932
dc.identifier.issn1980-5322
dc.identifier.pmid30892416
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.6061/clinics/2019/e739
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4633
dc.identifier.volume74en_US
dc.identifier.wosWOS:000461832600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHospital Clinicas, Sao Paul
dc.relation.ispartofClinics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOsteoporosis
dc.subjectPolymorphism
dc.subjectVitamin K Epoxide Reductase Complex Subunit-1 Gene
dc.subjectVertebral Fracture
dc.titleIs there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study
dc.typeArticle

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