Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms

dc.authorid0000-0001-9689-4018
dc.contributor.authorAhmed, Khaled Abdul-Aziz
dc.contributor.authorJabbar, Ahmed A. J.
dc.contributor.authorGalali, Yaseen
dc.contributor.authorM. Al-Qaaneh, Ayman
dc.contributor.authorAkçakavak, Gökhan
dc.contributor.authorSalehen, Nur Ain
dc.contributor.authorHassan, Rawaz Rizgar
dc.contributor.authorMothana, Ramzi A.
dc.date.accessioned2024-07-03T11:32:10Z
dc.date.available2024-07-03T11:32:10Z
dc.date.issued2024
dc.departmentVeteriner Fakültesi
dc.description.abstractWound healing is a complex, intricate, and dynamic process that requires effective therapeutic management. The current study evaluates the wound healing potentials of methanolic extract of Cuminum cyminum L. seeds (CCS) in rats. Sprague Dawley (24) rats were distributed into four cages, wounds produced on the back of the neck, and received two daily topical treatments for 14 days: A, rats received normal saline; B, wounded rats treated with intrasite gel; C and D, rats received 0.2 mL of 250 and 500 mg/kg of CCS, respectively. After that, wound area and closure percentage were evaluated, and wound tissues were dissected for histopathological, immunohistochemical, and biochemical examinations. Acute toxicity trials of methanolic extract of CCS showed the absence of any physiological changes or mortality in rats. CCS application caused a significant reduction in wound size and a statistically elevated percentage of wound contraction than those of vehicle rats. CCS treatment caused significant up-regulation of collagen fiber, fibroblasts, and fewer inflammatory cells (inflammation) in granulation tissues. TGF-?1 (angiogenetic factor) was significantly more expressed in CCS-treated rats in comparison to normal saline-treated rats; therefore, more fibroblasts transformed into myofibroblasts (angiogenesis). CCS-treated rats showed remarkable antioxidant potentials (higher SOD and CAT enzymes) and decreased MDA (lipid peroxidation) levels in their wound tissue homogenates. Hydroxyproline amino acid (collagen) was significantly up-regulated by CCS treatment, which is commonly related to faster wound closure area. The outcomes suggest CCS as a viable new source of pharmaceuticals for wound treatment.
dc.identifier.doi10.1111/srt.13727
dc.identifier.issn0909-752X
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2
dc.identifier.urihttps:/dx.doi.org/10.1111/srt.13727
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12031
dc.identifier.volume30en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofSkin Research and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidants
dc.subjectCuminum Cyminum L.
dc.subjectHistology
dc.subjectImmunohistochemistry
dc.subjectWound
dc.titleCumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Yükleniyor...
Küçük Resim
İsim:
ahmed-khaled abdul-aziz-2024.pdf
Boyut:
3.09 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama: