Could NCOA5 a novel candidate gene for multiple sclerosis susceptibility?

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dc.authorid0000-0002-3143-5475
dc.authorid0000-0002-4992-5915
dc.authorid0000-0003-1285-6589
dc.authorid0000-0003-3780-4021
dc.authorid0000-0002-5972-0147
dc.authorid0000-0002-1354-4598
dc.contributor.authorRüstemoğlu, Hüsniye
dc.contributor.authorArslan, Erdem
dc.contributor.authorAtasever, Sema
dc.contributor.authorÇevik, Betül
dc.contributor.authorTaşpınar, Filiz
dc.contributor.authorTurhan, Ahmet Bülent
dc.contributor.authorRüstemoğlu, Aydın
dc.date.accessioned2024-04-25T06:35:00Z
dc.date.available2024-04-25T06:35:00Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractMultiple sclerosis (MS) is an inflammatory immune-mediated demyelinating disease that causes a challenging and disabling condition. Environmental and genetic factors play a role in appearing the state of the disease. Recent studies have shown that nuclear cofactor genes may play a role in the pathogenesis of MS. NCOA5 is a nuclear receptor coactivator independent of AF2 that modulates ERa-mediated transcription. This gene is involved in the pathogenesis of diseases such as psoriasis, Behcet’s disease, and cancer. Methods and results: We investigated the relationship between the rs2903908 polymorphism of the NCOA5 gene and MS among 157 unrelated MS patients and 160 healthy controls by RT-PCR. The frequencies of the CC, CT, and TT genotypes were 19.87%, 37.82%, and 42.31%, respectively, for the MS group and 5.63%, 43.75%, and 50.62%, respectively, for the control group. The CC genotype and the C allele were found to be significantly higher in the patient group (the p values were 0.0002 and 0.003, respectively). Conclusions: The fact that the CC genotype was found to be significantly higher in the patient group compared to the control group (p = 0.0002) and that it had a statistically significantly higher OR value (OR, 95% CI = 4.16, 1.91–9.05) suggests that the C allele may recessively predispose to MS for this polymorphism. These results suggest for the first time that the NCOA5 gene may have an effect on the occurrence of MS through different molecular pathways, which are discussed in the manuscript.
dc.identifier.doi10.1007/s11033-023-08830-6
dc.identifier.endpage9341en_US
dc.identifier.issn0301-4851
dc.identifier.issue11en_US
dc.identifier.pmid37817021
dc.identifier.scopusqualityQ2
dc.identifier.startpage9335en_US
dc.identifier.urihttps:/dx.doi.org10.1007/s11033-023-08830-6
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11706
dc.identifier.volume50en_US
dc.identifier.wosWOS:001081835100004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Science and Business Media B.V.
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMultiple Sclerosis
dc.subjectNCOA5
dc.subjectPolymorphisms
dc.subjectSusceptibility
dc.titleCould NCOA5 a novel candidate gene for multiple sclerosis susceptibility?
dc.typeArticle

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