Effects of chrysin in cadmium-induced testicular toxicity in the rat; role of multi-pathway regulation

Basit Öğe Kaydı
dc.authorid0000-0002-6250-5093
dc.contributor.authorTuncer, Sibel Çiğdem
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorGür, Cihan
dc.contributor.authorAygörmez, Serpil
dc.contributor.authorKandemir, Fatih Mehmet
dc.date.accessioned2023-10-13T11:24:41Z
dc.date.available2023-10-13T11:24:41Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractCadmium (Cd) is a strong toxic agent and causes serious damage to testicular tissues. Chrysin (CHR) is a natural flavonoid with many effective properties, especially antioxidant, anti-inflammatory and anti-apoptotic properties. The current study describes new evidence for the ameliorative effects of CHR on oxidative stress, apoptosis, autophagy and inflammation pathways in Cd-induced testicular tissue toxicity. Methods: Thirty-five male Wistar rats were divided into five groups, control, Cd, CHR, Cd + CHR25, and Cd + CHR50. Cd was administered alone at a dose of 25 mg/kg body weight or in combination with CHR 25 mg/kg and CHR 50 mg/kg for 7 days. Cd and CHR were administered orally. Biochemical, molecular, and histological methods were used to investigate inflammation, apoptosis, autophagy, and oxidant pathways in testicular tissue. Results: Cd increased lipid peroxidation, JAK-2/STAT-3 levels, inflammation-related NF-?B, TNF-?, IL-1?, IL-6, COX-2, and iNOS levels, AKT-2, FOXO1, Bax, Apaf-1 and Caspase-3 levels, autophagic Beclin-1, LC3A and LC3B. The Cd also caused a decrease in the activities of antioxidant enzymes and GSH levels, antiapoptotic Bcl-2 levels. CHR, on the other hand, had the opposite effect of all these Cd-induced changes. Conclusions: Overall, the data of this study indicate that testicular damage associated with Cd toxicity could be ameliorated by CHR administration.
dc.identifier.doi10.1007/s11033-023-08715-8
dc.identifier.endpage8318en_US
dc.identifier.issn0301-4851
dc.identifier.issue10en_US
dc.identifier.pmid37592178
dc.identifier.scopusqualityQ2
dc.identifier.startpage8305en_US
dc.identifier.urihttps:/dx.doi.org10.1007/s11033-023-08715-8
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11166
dc.identifier.volume50en_US
dc.identifier.wosWOS:001051788000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Science and Business Media B.V.
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectApoptosis
dc.subjectCadmium
dc.subjectChrysin
dc.subjectInflammation
dc.subjectTesticular Toxicology
dc.subjectOxidative Stress
dc.titleEffects of chrysin in cadmium-induced testicular toxicity in the rat; role of multi-pathway regulation
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
tuncer-sibel cigdem-2023.pdf
Boyut:
1.89 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu