Evaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia

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dc.authorid0000-0003-0786-5077
dc.contributor.authorErdal, Hüseyin
dc.contributor.authorÇiftçiler, Rafiye
dc.contributor.authorTuncer, Sibel Çiğdem
dc.contributor.authorÖzcan, Oğuzhan
dc.date.accessioned2022-09-30T05:35:04Z
dc.date.available2022-09-30T05:35:04Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractThis is the first study to evaluate both the dynamic thiol-disulfide homeostasis and ischemia-modified albumin (IMA) levels in patients with chronic lymphocytic leukemia (CLL). Twenty-nine patients with CLL and 20 controls were included in the study. The dynamic thiol-disulfide balance was determined by the newly developed colorimetric method by Erel. IMA levels were determined by the cobalt binding test. We found that total antioxidant status levels were lower while total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly higher in patients with CLL than controls. Moreover, native and total thiol levels were found to be statistically significant between the study and control groups (p<0.001), whereas no statistically significant difference was noted for IMA levels (p=0.365). A negative correlation was observed between native and total thiol levels, leukocyte, lymphocyte, and TOS. Total bilirubin showed positive correlation with direct bilirubin and alkaline phosphatase. In addition, IMA levels showed a positive correlation with OSI. This study highlights measurement of native and total thiol and IMA levels in patients with CLL for the first time. Dynamic thiol-disulfide homeostasis may contribute in the pathophysiological mechanism, and follow-up to disease in patients with CLL.
dc.identifier.doi10.1136/jim-2022-002568
dc.identifier.endpage-en_US
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.issue-en_US
dc.identifier.pmid36038148
dc.identifier.scopusqualityQ2
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1136/jim-2022-002568
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9703
dc.identifier.volume-en_US
dc.identifier.wosWOS:000848648700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.relation.ispartofJournal of Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOxidants
dc.subjectLeukemia
dc.subjectHematologic
dc.subjectDiseases
dc.subjectHematology
dc.titleEvaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia
dc.typeArticle

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