Protective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study
| dc.authorid | 0000-0001-9912-174X | |
| dc.authorid | 0000-0002-8490-2479 | |
| dc.authorid | 0000-0001-5608-554X | |
| dc.authorid | 0000-0001-5367-0743 | |
| dc.authorid | 0000-0003-0376-5589 | |
| dc.contributor.author | Semis, Halil S. | |
| dc.contributor.author | Kandemir, Fatih M. | |
| dc.contributor.author | Çağlayan, Cüneyt | |
| dc.contributor.author | Kaynar, Özgür | |
| dc.contributor.author | Genç, Aydın | |
| dc.contributor.author | Arıkan, Şefik M. | |
| dc.date.accessioned | 2022-06-27T05:35:01Z | |
| dc.date.available | 2022-06-27T05:35:01Z | |
| dc.date.issued | 2022 | |
| dc.department | Tıp Fakültesi | |
| dc.description.abstract | Oxaliplatin (OXL) is a chemotherapeutic drug used for metastatic and other types of cancer, but it causes peripheral neuropathy as a dose-limiting side effect. Herein, we used the rat model of OXL-induced peripheral neuropathy to demonstrate the protective effects of naringin (NRG) in this neuropathy. In this study, rats were injected with OXL (4 mg/kg, body weight, i.p.) in 5% glucose solution 30 min after oral administration of NRG (50 and 100 mg/kg, body weight) on the 1st, 2nd, 5th, and 6th days. OXL caused sensory and motor neuropathy (as revealed by the hot plate, tail flick, rota-rod, and cold hyperalgesia tests) in the sciatic nerve of rats. Coadministration of oral NRG alleviated OXL-induced sensory and motor neuropathy. Levels of superoxide dismutase, catalase, glutathione peroxidase, nuclear factor erythroid 2-related factor 2, Heme oxygenase-1, nuclear factor-kappa B, tumor necrosis factor-alpha, interleukin-1 beta, Bax, Bcl-2, caspase-3, paraoxonase, mitogen-activated protein kinase 14, neuronal nitric oxide synthase (nNOS), acetylcholinesterase, and arginase 2 in the sciatic nerve tissues were assessed by real-time polymerase chain reaction. Moreover, the protein levels of caspase-3, Bax, Bcl-2, intercellular adhesion molecules-1, glial fibrillary acidic protein, and nNOS were examined by Western blot analysis. NRG treatment significantly improved all the above-mentioned parameters and reduced OXL-induced oxidative stress, inflammation, and apoptosis in the sciatic nerve tissue. In conclusion, this study demonstrated that NRG significantly attenuated OXL-induced peripheral neuropathy and might be considered as a new protective agent to prevent the OXL-induced peripheral neuropathy. | |
| dc.identifier.doi | 10.1002/jbt.23121 | |
| dc.identifier.endpage | - | en_US |
| dc.identifier.issn | 1095-6670 | |
| dc.identifier.issn | 1099-0461 | |
| dc.identifier.issue | - | en_US |
| dc.identifier.pmid | 35670529 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | - | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.1002/jbt.23121 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/9483 | |
| dc.identifier.volume | - | en_US |
| dc.identifier.wos | WOS:000806994700001 | |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | Journal of Biochemical and Molecular Toxicology | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Apoptosis | |
| dc.subject | Inflammation | |
| dc.subject | Oxaliplatin | |
| dc.subject | Oxidative Stress | |
| dc.subject | Peripheral Neuropathy | |
| dc.title | Protective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study | |
| dc.type | Article |
