Genomewide association of male reproductive traits in Aksaray Malakli dogs

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dc.authoridCINAR KUL, Bengi -- 0000-0002-8955-0097; INANC, MUHAMMED ENES -- 0000-0001-6954-6309
dc.contributor.authorİnanç, Muhammed Enes
dc.contributor.authorTekin, Koray
dc.contributor.authorAkkurt, Mustafa Yenal
dc.contributor.authorOlgaç, Kemal Tuna
dc.contributor.authorYılmaz, Burak
dc.contributor.authorÇil, Beste
dc.contributor.authorKızılaslan, Mehmet
dc.contributor.authorTaşdemir, Umut
dc.contributor.authorTuncer, Purhan Barbaros
dc.contributor.authorBüyükleblebici, Serhat
dc.contributor.authorUysal, Ongun
dc.contributor.authorÇınar Kul, Bengi
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:15:11Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:15:11Z
dc.date.issued2018
dc.departmentAksaray Teknik Bilimler Meslek Yüksekokulu
dc.description.abstractMale reproductive parameters are often used for the functional examination and evaluation of predicted genetic values for future aspects. However, these traits are relatively reliable until the measurable effects are expressed on desired traits. Therefore, we aimed to associate the single nucleotide polymorphism (SNP) genotype of the investigated characteristics and reproductive loci. A total of 46 male dogs are divided into three age groups (I <= 3 years, n = 19; II 4-6 years; n = 19, and III >= 7 years, n = 8). The testis, scrotum and body weight, libido sexualis and ejaculation time for each fraction were monitored as functional traits, while the pH, fractional semen volume, motility, concentration, and abnormal and dead spermatozoa rate were recorded as spermatological traits. The Affymetrix Canine 127 K SNP genotyping array v2 (Affymetrix Inc., California, USA) was used for SNP genotyping. In the primary results, the scrotal circumference was found to be higher in group II compared to other groups (p < 0.05) and the lowest total abnormal spermatozoa rate was found in group I (p < 0.05). The normal spermatozoa rate was found to be significantly above the threshold in relation to the SNP in chromosome 17. In conclusion, this study represents an exciting first step towards SNP association with dog semen spermatological parameters. Future studies might be undertaken to evaluate this SNP region for gene-knockout and expression analysis and for fine mapping to validate and/or discover the exact position of the effect region.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114O636]
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK), Grant/Award Number: 114O636
dc.identifier.doi10.1111/rda.13302
dc.identifier.endpage1562en_US
dc.identifier.issn0936-6768
dc.identifier.issn1439-0531
dc.identifier.issue6en_US
dc.identifier.pmid30085374
dc.identifier.scopusqualityQ2
dc.identifier.startpage1555en_US
dc.identifier.urihttps://doi.org/10.1111/rda.13302
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4315
dc.identifier.volume53en_US
dc.identifier.wosWOS:000449849900037
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofReproduction in Domestic Animals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectGWAS Analysis
dc.subjectMalakli Dog
dc.subjectSingle Nucleotide Polymorphism
dc.subjectSpermatological Parameters
dc.titleGenomewide association of male reproductive traits in Aksaray Malakli dogs
dc.typeArticle

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