Decrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis

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dc.authorid0000-0002-4597-6811
dc.authorid0000-0001-9659-2503
dc.authorid0000-0002-1362-1717
dc.authorid0000-0003-3312-6630
dc.authorid0000-0002-1361-0751
dc.authorid0000-0001-5806-8241
dc.authorid0000-0002-5522-0647
dc.contributor.authorMehmetbeyoğlu, Ecmel
dc.contributor.authorKianmehr, Leila
dc.contributor.authorBorlu, Murat
dc.contributor.authorYılmaz, Zeynep
dc.contributor.authorKılıç, Şeyma Başar
dc.contributor.authorRajabi-Maham, Hassan
dc.contributor.authorTaheri, Serpil
dc.contributor.authorRassoulzadegan, Minoo
dc.date.accessioned2022-05-12T05:33:23Z
dc.date.available2022-05-12T05:33:23Z
dc.date.issued2022
dc.departmentTıp Fakültesi
dc.description.abstractFunctional long non-coding RNAs (lncRNAs) have been in the limelight in aging research because short telomeres are associated with higher levels of TERRA (Telomeric Repeat containing RNA). The genomic instability, which leads to short telomeres, is a mechanism observed in cell aging and in a class of cancer cells. Psoriasis, a skin disease, is a disorder of epidermal keratinocytes, with altered telomerase activity. Research on the fraction of nascent RNAs in hybrid with DNA offers avenues for new strategies. Skin and blood samples from patients were fractionated to obtain the RNA associated with DNA as a R-loop structure. The higher amount of TERRA levels attached with each chromosome end was found with psoriasis patients in blood and skin. In addition to telomeric TERRA, we evidenced accumulation of others non-coding RNA, such as non-telomeric TERRA and centromeric transcripts. Increased levels of non-coding RNAs attached to DNA correlates with a decreased in Ribonuclease HII (RNase-HII) transcript which means that overall unresolved DNA–RNA hybrids can ultimately weaken DNA and cause skin lesions. Since the genome is actively transcribed, cellular RNase-HII is essential for removing RNA from the DNA–RNA hybrid in controls of genome stability and epigenome shaping and can be used as a causal prognostic marker in patients with psoriasis.
dc.identifier.doi10.3390/biom12030368
dc.identifier.endpage-en_US
dc.identifier.issn2218-273X
dc.identifier.issue3en_US
dc.identifier.pmid35327560
dc.identifier.scopusqualityQ1
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.3390/biom12030368
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9374
dc.identifier.volume12en_US
dc.identifier.wosWOS:000775765100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofBiomolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectPsoriasis
dc.subjectNon-coding RNAs
dc.subjectTelomere Length
dc.subjectRNA–DNA Hybrid
dc.subjectTERRA
dc.subjectRNase HII
dc.subjectCentromeres
dc.subjectEpigenetics
dc.subjectCancer
dc.titleDecrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis
dc.typeArticle

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