Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy

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dc.authoridBayram, Cem -- 0000-0001-8717-4668;
dc.contributor.authorKılıçay, Ebru
dc.contributor.authorKarahaliloğlu, Zeynep
dc.contributor.authorHazer, Baki
dc.contributor.authorTekin, İshak Özel
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:02Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:02Z
dc.date.issued2016
dc.departmentSabire Yazıcı Fen-Edebiyat Fakültesi
dc.description.abstractThe aim of this study was to evaluate therapeutic potential of curcumin-loaded poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) PHBHHx nanoparticles (CUR-NPs) and concanavaline A conjugated curcumin-loaded NPs (ConA-CUR-NPs) for breast cancer treatment. The size and zeta potential of prepared NPs were about 228 +/- 5nm and -23.3mV, respectively. The entrapment efficiencies of polymer/drug weight ratios, 1.25CUR-NPs, 2.5CUR-NPs, 5CUR-NPs, ConA-1.25CUR-NPs, ConA-2.5CUR-NPs and ConA-5CUR-NPs were found to be approximate to 68, 55, 45, 70, 60 and 51%, respectively. Optimized NPs formulations in the freeze-dried form were assessed with their short-term stability for 30 days of storage at 4 degrees C and 25 degrees C. Anticancer activity of ConA-CUR-NPs was proved by MTT assay and reconfirmed by double staining and flow cytometry results. The anticancer activity of ConA-CUR-NPs was measured in human breast cancer cells (MDA-MB 231) in vitro, and the results revealed that the ConA-CUR-NPs had better tumor cells decline activity.
dc.description.sponsorshipBulent Ecevit University [BEU-2015-YKD-33496813-01]
dc.description.sponsorshipThis work was financially supported by the Bulent Ecevit University for oral presentation in ICBN 2015: 17th International Conference on Biotechnology and Nanotechnology, 2015, Venice, Italy. Research Fund (Grant no. BEU-2015-YKD-33496813-01).
dc.identifier.doi10.3109/02652048.2016.1169325
dc.identifier.endpage285en_US
dc.identifier.issn0265-2048
dc.identifier.issn1464-5246
dc.identifier.issue3en_US
dc.identifier.pmid27049468
dc.identifier.scopusqualityQ2
dc.identifier.startpage274en_US
dc.identifier.urihttps://doi.org/10.3109/02652048.2016.1169325
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5973
dc.identifier.volume33en_US
dc.identifier.wosWOS:000376996300009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofJournal of Microencapsulation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPHBHHx
dc.subjectPHBHHx Nanoparticles
dc.subjectCurcumin
dc.subjectConcanavaline A
dc.subjectDrug Delivery
dc.subjectHuman Breast Cancer Cells
dc.titleConcanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy
dc.typeArticle

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