Synthesis, characterization, and exosomal corona formation of self-assembled dipeptide nanomaterials

Basit Öğe Kaydı
dc.contributor.authorÖnal Acet, Burcu
dc.contributor.authorAcet, Ömür
dc.contributor.authorWandrey, Madita
dc.contributor.authorStauber, Roland H.
dc.contributor.authorGül, Désirée
dc.contributor.authorOdabaşı, Mehmet
dc.date.accessioned2025-07-08T05:48:53Z
dc.date.available2025-07-08T05:48:53Z
dc.date.issued2025
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractExosomes (Exos), also known as small extracellular vesicles, are naturally occurring nanoparticles (NPs), which are characterized by their nanometer size and negative charged in physiological environments. While it is widely accepted that proteins and biological compounds adhere to different nanomaterials (NMs), forming an outer layer known as the biomolecule corona (BC), the detailed understanding of factors contributing to BC formation as well as of its biological effects remains limited. Studies have shown that BC formation can affect the physicochemical properties of synthetic and natural NPs once contacting biological fluids. Here, we present a study investigating the novel concept of exosomal corona formation, which in contrast to the well-documented BC mainly consists of Exos/exosomal components. For this purpose, peptide-based Fmoc-Lysine (Fmoc-Lys) NMs were synthesized and characterized, and interaction studies with (cancer) cell-derived Exos were performed. Measurements of size, zeta potential, and colloidal stability indicate exosomal corona formation. Furthermore, cell viability experiments showed that the Exo-NM interaction resulted in reduced nanotoxicity profile indicating practical relevance for biological applications of these NMs. In summary, here we provide first evidence supporting the concept of exosomal corona formation around NMs that should become part of evaluating interactions at nano-bio-interfaces.
dc.identifier.doi10.1038/s41598-025-98706-5
dc.identifier.issn20452322
dc.identifier.issue1
dc.identifier.pmid40253485
dc.identifier.scopus105003287460
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1038/s41598-025-98706-5
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13189
dc.identifier.volume15
dc.identifier.wos001470004100005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorÖnal Acet, Burcu
dc.institutionauthorOdabaşı, Mehmet
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiomolecule Corona
dc.subjectDipeptides
dc.subjectExosomal Corona
dc.subjectExosome
dc.subjectExtracellular Vesicles
dc.subjectFmoc-Lysin Nanomaterials
dc.titleSynthesis, characterization, and exosomal corona formation of self-assembled dipeptide nanomaterials
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
onal acet-burcu-2025.pdf
Boyut:
1.78 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu