Exploring the polygenic landscape of wool traits in Turkish Merinos through multi-locus GWAS approaches: middle Anatolian Merino

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dc.authorid0000-0003-2705-2831
dc.contributor.authorYaman, Yalçın
dc.contributor.authorÖnaldı, A. Taner
dc.contributor.authorDoğan, Şükrü
dc.contributor.authorKırbaş, Mesut
dc.contributor.authorBehrem, Sedat
dc.date.accessioned2025-04-22T06:38:47Z
dc.date.available2025-04-22T06:38:47Z
dc.date.issued2025
dc.departmentVeteriner Fakültesi
dc.description.abstractThis study investigates the genetic underpinnings of wool traits, specifically fibre diameter (FD) and staple length (SL), in Middle Anatolian Merino sheep using multi-locus genome-wide association study (GWAS) approaches. Representing the first attempt to examine these polygenic traits with multi-locus methods, the analysis employed four techniques: mrMLM, FASTmrMLM, FASTmrEMMA, and ISIS EM-BLASSO. A total of 18 Quantitative Trait Nucleotides (QTNs) were identified for FD, with 7 co-detected by multiple methods, and 14 QTNs were identified for SL, with 5 co-detected by multiple methods. Post-hoc power analysis revealed high statistical power for both traits (FD: 0.95, SL: 0.91). Notably, three candidate genes—PTPN3, TCF4, and ZBTB8A—were found to be consistent with prior studies. Gene enrichment and pathway analyses reaffirmed the complex and multifactorial molecular mechanisms governing wool traits. These findings enhance our understanding of the polygenic nature of wool traits, shedding light on the intricate genetic regulation and pinpointing genomic regions potentially influencing wool physiology. By identifying specific QTNs associated with FD and SL, this research provides a foundation for elucidating the genetic mechanisms underlying these economically significant traits. Upon validation in diverse populations, these findings hold substantial promise for the application of marker-assisted selection (MAS) to improve wool traits.
dc.identifier.doi10.1038/s41598-025-95099-3
dc.identifier.issn20452322
dc.identifier.issue1
dc.identifier.pmid40148429
dc.identifier.scopus2-s2.0-105001250320
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1038/s41598-025-95099-3
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13092
dc.identifier.volume15
dc.identifier.wos001455386100035
dc.identifier.wosqualityQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorBehrem, Sedat
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDual-purpose Breeding
dc.subjectGrowth Performance
dc.subjectMiddle Anatolian Merino
dc.subjectMulti-locus GWAS
dc.subjectWool Traits
dc.titleExploring the polygenic landscape of wool traits in Turkish Merinos through multi-locus GWAS approaches: middle Anatolian Merino
dc.typeArticle

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