Nigella sativa improves the carbon tetrachloride-induced lung damage in rats through repression of erk/akt pathway
| dc.authorid | 0000-0002-6243-4221 | |
| dc.contributor.author | Aslan, Abdullah | |
| dc.contributor.author | Boydak, Didem | |
| dc.contributor.author | Can, Muhammed İsmail | |
| dc.contributor.author | Kuloğlu, Tuncay | |
| dc.date.accessioned | 2019-07-11T13:05:04Z | |
| dc.date.available | 2019-07-11T13:05:04Z | |
| dc.date.issued | 2015 | |
| dc.department | Sabire Yazıcı Fen Edebiyat Fakültesi | |
| dc.description | Can, Muhammed İsmail (Aksaray, Yazar) | |
| dc.description.abstract | The objective of this study was to examine whether Nigella sativa plays a protective role against the damage in the lung by administering carbon tetra-chloride (CCl4) to rats. Male Wistar albino (n=28, 8 weeks old) rats were divided into 4 groups: a) negative control: Normal water consuming group to which no CCl4 and N. sativa was administered; b) Positive control: Normal water consuming group to which no CCl4 was administered but N. sativa was administered; c) CCl4 Group: Normal water consuming and group to which CCl4 was administered (1.5 mL/kg, ip); d) N. sativa plus CCl4group: CCl4and N. sativa administered group (1.5 mL/kg, ip). Caspase-3, caspase -9, erk, akt protein syntheses were examined via Western blotting. Malondialdehyde determination in lung tissue was made using spectrophotometer. As a results, malondialdehyde amount was decreased in the CCl4 plus N. sativa group in comparison to CCl4 group whereas caspase-3, caspase-9 was increased and erk, akt had decreased. These results show that N. sativa protects the lung against oxidative damage. | |
| dc.identifier.endpage | 659 | en_US |
| dc.identifier.issn | 1991-007X | |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.scopusquality | Q4 | |
| dc.identifier.startpage | 654 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/2168 | |
| dc.identifier.volume | 10 | en_US |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | Bangladesh Pharmacological Society | |
| dc.relation.ispartof | Bangladesh Journal of Pharmacology | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.title | Nigella sativa improves the carbon tetrachloride-induced lung damage in rats through repression of erk/akt pathway | |
| dc.type | Article |
