Nigella sativa improves the carbon tetrachloride-induced lung damage in rats through repression of erk/akt pathway
Yükleniyor...
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bangladesh Pharmacological Society
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The objective of this study was to examine whether Nigella sativa plays a protective role against the damage in the lung by administering carbon tetra-chloride (CCl4) to rats. Male Wistar albino (n=28, 8 weeks old) rats were divided into 4 groups: a) negative control: Normal water consuming group to which no CCl4 and N. sativa was administered; b) Positive control: Normal water consuming group to which no CCl4 was administered but N. sativa was administered; c) CCl4 Group: Normal water consuming and group to which CCl4 was administered (1.5 mL/kg, ip); d) N. sativa plus CCl4group: CCl4and N. sativa administered group (1.5 mL/kg, ip). Caspase-3, caspase -9, erk, akt protein syntheses were examined via Western blotting. Malondialdehyde determination in lung tissue was made using spectrophotometer. As a results, malondialdehyde amount was decreased in the CCl4 plus N. sativa group in comparison to CCl4 group whereas caspase-3, caspase-9 was increased and erk, akt had decreased. These results show that N. sativa protects the lung against oxidative damage.
Açıklama
Can, Muhammed İsmail (Aksaray, Yazar)
Anahtar Kelimeler
Kaynak
Bangladesh Journal of Pharmacology
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
10
Sayı
3
