Exploring Genetic Factors Associated with Moniezia spp. Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach

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dc.authorid0000-0002-3068-8155
dc.authorid0000-0001-6305-8742
dc.authorid0000-0002-7351-1229
dc.authorid0000-0003-0428-6467
dc.authorid0000-0001-5894-5072
dc.authorid0000-0001-9255-6054
dc.contributor.authorArzık, Yunus
dc.contributor.authorKızılaslan, Mehmet
dc.contributor.authorBehrem, Sedat
dc.contributor.authorPiel, Lindsay M. W.
dc.contributor.authorWhite, Stephen N.
dc.contributor.authorÇınar, Mehmet Ulaş
dc.date.accessioned2025-07-14T12:14:09Z
dc.date.available2025-07-14T12:14:09Z
dc.date.issued2025
dc.departmentVeteriner Fakültesi
dc.description.abstractGastrointestinal parasite (GIP) infections are a major challenge in pasture-based sheep farming, leading to both economic losses and animal welfare concerns. This study aimed to identify genetic factors that contribute to resistance against tapeworm (Moniezia spp.) infections in Central Anatolian Merino (CAM) sheep. We conducted genome-wide association studies (GWAS) on 226 CAM lambs, analyzing their genetic data in relation to Moniezia spp. egg burden. Thirteen significant genetic markers (SNPs) were identified. Two key immune-related genes, CD79A and MAP3K7, were linked to parasite resistance. CD79A is essential for B-cell activation and antibody production, while MAP3K7 regulates immune responses, particularly through NF-κB signaling. These findings highlight the potential for using genetic information to improve disease resistance in livestock breeding programs. Further research is needed to understand the role of these genes and to explore host–parasite interactions in more detail.
dc.identifier.doi10.3390/ani15060812
dc.identifier.issn20762615
dc.identifier.issue6
dc.identifier.scopus105002018259
dc.identifier.urihttps://dx.doi.org/10.3390/ani15060812
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13293
dc.identifier.volume15
dc.identifier.wosWOS:001453597000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorArzık, Yunus
dc.institutionauthorBehrem, Sedat
dc.institutionauthorid0002-7351-1229
dc.institutionauthorid0000-0002-3068-8155
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofAnimals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCD79A Gene
dc.subjectGenome-wide Association
dc.subjectMAP3K7 Gene
dc.subjectMonieziaspp
dc.subjectOvis Aries
dc.subjectParasite Resistance
dc.titleExploring Genetic Factors Associated with Moniezia spp. Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach
dc.typeArticle

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