Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome

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dc.authorid0000-0003-1496-3732
dc.contributor.authorSoykan Sert, Zekiye
dc.contributor.authorYılmaz, Setenay Arzu
dc.contributor.authorSeçilmiş, Özlem
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorÜnlü, Ali
dc.contributor.authorÇelik, Çetin
dc.date.accessioned2022-02-25T06:09:12Z
dc.date.available2022-02-25T06:09:12Z
dc.date.issued2022
dc.departmentTıp Fakültesi
dc.description.abstractIn this study, we investigated the effect of calcium and vitamin D (Ca/Vit D) supplementation on the clinical, hormonal, and metabolic profile of patients with low vitamin D levels. In addition, we investigated the effect of Ca/Vit D supplementation on asymmetric dimethylarginine (ADMA) level in patients with polycystic ovary syndrome (PCOS). Methods: In total, 75 patients aged 19–35 years, with a normal body mass index and a diagnosis of PCOS and Vit D deficiency/insufficiency, were included in the study. Patients received 50,000 IU of vitamin D3 once a week for 8 weeks. Afterward, 2500 mg calcium carbonate equivalent to 1000 mg calcium ion and 9.68 mg cholecalciferol equivalent to 880 IU vitamin D3 were administered orally as a maintenance treatment once a day. Results: The mean age of the patients was 21.7 ± 3.5. After Ca/Vit D supplementation, Vit D levels significantly increased compared to baseline (8.6 ng/ml) levels. An increase in SHBG levels (p < 0.001), a decrease in total testosterone, FAI (p = 0.042), and ADMA levels (p < 0.001) were observed in the first and third months compared to the onset. Significant improvement compared to baseline was observed in menstrual irregularity and median mFG score. Conclusion: Ca/Vit D supplementation can improve PCOS symptoms such as menstrual dysfunction, hirsutism, and hyperandrogenism. It may be effective in reducing the risk of cardiovascular disease in patients with PCOS later in life by decreasing ADMA levels, which is an indicator of endothelial dysfunction.
dc.identifier.doi10.1007/s11845-021-02899-3
dc.identifier.endpage-en_US
dc.identifier.issn0021-1265
dc.identifier.issue-en_US
dc.identifier.pmid35088227
dc.identifier.scopusqualityQ1
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1007/s11845-021-02899-3
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9230
dc.identifier.volume-en_US
dc.identifier.wosWOS:000749233000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofIrish Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAsymmetric Dimethylarginine
dc.subjectCalcium
dc.subjectPolycystic Ovary Syndrome
dc.subjectVitamin D Supplementation
dc.titleEffect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome
dc.typeArticle

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