Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI

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dc.authoridderyanur -- 0000-0002-9115-136X; Senturk, Murat -- 0000-0001-5968-7511
dc.contributor.authorAlp, Cemalettin
dc.contributor.authorÖzsoy, Şeyda
dc.contributor.authorAlp, Nurdan Alcan
dc.contributor.authorErdem, Deryanur
dc.contributor.authorGültekin, Mehmet Serdar
dc.contributor.authorKüfrevioğlu, Ömer İrfan
dc.contributor.authorŞentürk, Murat
dc.contributor.authorSupuran, Claudiu T.
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:26:20Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:26:20Z
dc.date.issued2012
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and human serum isozyme VI, with a series of tosylited aromatic amine derivatives was investigated. The K-I ranges of compounds 1-14 and acetazolamide against hCA I ranged between 1.130 and- 448.2 mu M, against hCA II between 0.103 and- 14.3 mu M, and against hCA VI ranged between 0.340 and- 42.39 mu M. Tosylited aromatic amine derivatives are thus interesting hCA I, II and VI inhibitors, and might be used as leads for generating enzyme inhibitors eventually targeting other isoforms which have not been assayed yet for their interactions with such agents.
dc.description.sponsorshipTurkish Republic Prime Ministry State Planning Organization (DPT) [2010K120440]; Agri Ibrahim Cecen University Scientific Research Council [Agri BAP-2010/K-10]
dc.description.sponsorshipThis study was financed by Turkish Republic Prime Ministry State Planning Organization (DPT), (project no: 2010K120440) and Agri Ibrahim Cecen University Scientific Research Council, (project no: Agri BAP-2010/K-10) for (MS).
dc.identifier.doi10.3109/14756366.2011.617745
dc.identifier.endpage824en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue6en_US
dc.identifier.pmid22188522
dc.identifier.scopusqualityQ1
dc.identifier.startpage818en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2011.617745
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5543
dc.identifier.volume27en_US
dc.identifier.wosWOS:000311682500007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbonic Anhydrase
dc.subjectInhibition
dc.subjectBenzenesulfonamides
dc.titleSulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI
dc.typeArticle

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