Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI
Yükleniyor...
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and human serum isozyme VI, with a series of tosylited aromatic amine derivatives was investigated. The K-I ranges of compounds 1-14 and acetazolamide against hCA I ranged between 1.130 and- 448.2 mu M, against hCA II between 0.103 and- 14.3 mu M, and against hCA VI ranged between 0.340 and- 42.39 mu M. Tosylited aromatic amine derivatives are thus interesting hCA I, II and VI inhibitors, and might be used as leads for generating enzyme inhibitors eventually targeting other isoforms which have not been assayed yet for their interactions with such agents.
Açıklama
Anahtar Kelimeler
Carbonic Anhydrase, Inhibition, Benzenesulfonamides
Kaynak
Journal of Enzyme Inhibition and Medicinal Chemistry
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
27
Sayı
6
