Aberrant expressions of leptin and adiponectin receptor isoforms in chronic myeloid leukemia patients

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dc.contributor.authorÖztürk, Kamile
dc.contributor.authorAvcu, Ferit
dc.contributor.authorUral, A. Uğur
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:09Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:09Z
dc.date.issued2012
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractBackground: Leptin and adiponectin receptors mediate the role of leptin in stimulating the growth of leukemic cells and the protective function of adiponectin undertaken in several malignancies such as leukemia. In this study, we investigated the involvement of the expression of leptin and adiponectin receptors in chronic myeloid leukemia (CML) pathogenesis. Methods: The expression of leptin receptor isoforms, OB-Rt, OB-Ra, and OB-Rb, and the expression of adiponectin receptors, AdipoR1 and AdipoR2, were measured as mRNA levels in two CML cell lines (K562 and Meg-01) and 20 CML patients and 24 healthy controls by using RT-PCR. Results: OB-Rt and OB-Ra isoforms expression of the leptin receptors were found to be significantly lower in Meg-01 cell lines than K562 cells. All leptin receptors were downregulated in CML patients and more particularly OB-Rb level was found to be undetectably low in normal PBMC as well as in CML patients. AdipoR1 expression level was higher in Meg-01 than in K562, whereas AdipoR2 level was found to be unchanged in both cell lines. Interestingly, while AdipoR1 expression increased in CML patients, AdipoR2 decreased. Moreover, imatinib therapy did not affect both leptin and adiponectin isoform expressions. Conclusion: While the decrease in leptin receptor levels in CML patients was confirmed, the increase in AdipoR1 levels and relevant decrease in AdipoR2 levels depicted their possible involvement in CML pathogenesis. This suggests different functions of adiponectin receptors in CML development. (C) 2011 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipGulhane Military Medical Academy
dc.description.sponsorshipThis work was supported by Gulhane Military Medical Academy Research Fund.
dc.identifier.doi10.1016/j.cyto.2011.10.004
dc.identifier.endpage67en_US
dc.identifier.issn1043-4666
dc.identifier.issue1en_US
dc.identifier.pmid22082804
dc.identifier.scopusqualityQ1
dc.identifier.startpage61en_US
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2011.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5800
dc.identifier.volume57en_US
dc.identifier.wosWOS:000299580800011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press
dc.relation.ispartofCytokine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectLeptin Receptors
dc.subjectAdiponectin Receptors
dc.subjectChronic Myeloid Leukemia
dc.titleAberrant expressions of leptin and adiponectin receptor isoforms in chronic myeloid leukemia patients
dc.typeArticle

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