Random start ovarian stimulation before gonadotoxic therapies in women with cancer: a systematic review and meta-analysis

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dc.contributor.authorSönmezer, Murat
dc.contributor.authorŞükür, Yavuz Emre
dc.contributor.authorAteş, Can
dc.contributor.authorSaçıntı, Koray Görkem
dc.contributor.authorSönmezer, Meltem
dc.contributor.authorAslan, Batuhan
dc.contributor.authorAtabekoğlu, Cem Somer
dc.contributor.authorÖzmen, Batuhan
dc.contributor.authorOktay, Kutlu H.
dc.date.accessioned2023-10-24T10:53:05Z
dc.date.available2023-10-24T10:53:05Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractThe aim of this systematic review and meta-analysis was to quantify the effect of random start ovarian stimulation (RSOS) compared with conventional start ovarian stimulation (CSOS) in cancer patients before gonadotoxic treatment. The final analytical cohort encompassed 688 RSOS and 1076 CSOS cycles of cancer patients before gonadotoxic treatment. Eleven studies were identified by database searches of MEDLINE, Cochrane Library and cited references. The primary outcomes of interest were the number of oocytes and mature oocytes collected, the number of embryos cryopreserved and the metaphase II (MII)-antral follicle count (AFC) ratio. The studies were rated from medium to high quality (from 6 to 9) according to the Newcastle-Ottawa Quality Assessment Scale. The two protocols resulted in similar numbers of oocytes collected, MII oocytes, embryos available for cryopreservation and comparable MII-AFC and fertilization rates. The duration of ovarian stimulation was longer (standardized mean difference [SMD] 0.35, 95% CI 0.09 to 0.61; P = 0.009) and gonadotrophin consumption was higher (SMD 0.23, 95% CI 0.06 to 0.40; P = 0.009) in RSOS compared with CSOS. This systematic review and meta-analysis show that the duration of stimulation is longer, and the total gonadotrophin consumption is higher in cancer patients undergoing RSOS compared with those undergoing CSOS, with no significant effect on mature oocyte yield.
dc.identifier.doi10.1016/j.rbmo.2023.103337
dc.identifier.issue6en_US
dc.identifier.pmid37857156
dc.identifier.scopusqualityQ1
dc.identifier.urihttps:/dx.doi.org103337. doi: 10.1016/j.rbmo.2023.103337
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11215
dc.identifier.volume47en_US
dc.identifier.wosWOS:001159684200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCambridge, UK : Reproductive Healthcare Ltd.
dc.relation.ispartofReproductive Biomedicine Online
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectChemotherapy
dc.subjectFertility Preservation
dc.subjectGonadotoxic Therapies
dc.subjectOvarian Stimulation
dc.subjectRandom start Ovarian Stimulation
dc.titleRandom start ovarian stimulation before gonadotoxic therapies in women with cancer: a systematic review and meta-analysis
dc.typeReview Article

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