Exposure to a 0.9-GHz electromagnetic field on postnatal days 21–45 may trigger the renin-angiotensin system in male rat: a histological and biochemical study

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dc.authorid0000-0003-0716-5695
dc.authorid0000-0003-3060-000X
dc.authorid0000-0002-4875-9820
dc.authorid0000-0002-9121-536X
dc.authorid0000-0002-8506-1755
dc.authoridhttps://orcid.org/0000-0002-4644-477X
dc.contributor.authorİkinci Keleş, Ayşe
dc.contributor.authorKaya, Haydar
dc.contributor.authorKeleş, Gökhan
dc.contributor.authorErol, Hüseyin Serkan
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorOdacı, Ersan
dc.date.accessioned2025-04-17T06:54:20Z
dc.date.available2025-04-17T06:54:20Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractThe aim of this study was to examine the relationship between the renin-angiotensin system (RAS) and histological and biochemical changes occurring in the kidney tissue of male rats exposed to a 0.9 GHz electromagnetic field (EMF). Twelve male rats aged 21 days were randomly assigned to control (C-Gr) and EMF (EMF-Gr) groups. No procedure was performed on C-Gr, while the EMF-Gr rats were exposed to a 0.9 GHz EMF on postnatal days 21–45 (one hour a day for 25 days). Tissues were removed at the end of the experiment and evaluated using biochemical, and histopathological methods. Increased kidney tissue volume and weight and total body weight were determined in the group exposed to EMF. Lipid peroxidation, glutathione, catalase, and superoxide dismutase also increased in the kidney tissue of the EMF-Gr rats. Histopathological evaluation revealed cortical/medullary bleeding/obstruction and widespread fibrosis, dilatation, vacuolization, and degeneration in distal and proximal tubules, decreased and atypical parietal cells, and degeneration in epithelial cells. Additionally, dilated and degenerated glomeruli in the Malpighian body, Bowman’s membrane degeneration and degeneration in the vascular pole, podocyte, pedicel and mesangial cells were also observed. As a result of exposure to EMF, oxidative stress, tissue volume and weight increased, and histopathological changes caused the formation of a pathway that triggers RAS in kidney tissues. In conclusion, long-term exposure to 0.9 GHz EMF can activate the renin-angiotensin system in the rat kidney, and we think that such activation may be associated with structural, histopathological, and biochemical changes occurring in renal tissue.
dc.identifier.doi10.1007/s10735-024-10317-y
dc.identifier.issn15672379
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85211357604
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1007/s10735-024-10317-y
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13070
dc.identifier.volume56
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.institutionauthorİkinci Keleş, Ayşe
dc.institutionauthorKeleş, Gökhan
dc.institutionauthorOdacı, Ersan
dc.institutionauthorid0000-0003-0716-5695
dc.institutionauthorid0000-0002-4875-9820
dc.institutionauthorid0000-0002-4644-477X
dc.language.isoen
dc.publisherSpringer Science and Business Media B.V.
dc.relation.ispartofJournal of Molecular Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectElectromagnetic Field
dc.subjectRenin-angiotensin System
dc.subjectMale Rat
dc.subjectOxidative Stress
dc.titleExposure to a 0.9-GHz electromagnetic field on postnatal days 21–45 may trigger the renin-angiotensin system in male rat: a histological and biochemical study
dc.typeArticle

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