Effects of pregnancy on chronic urticaria: Results of the PREG-CU UCARE study
| dc.contributor.author | Kocatürk, Emek | |
| dc.contributor.author | Al- Ahmad, Mona | |
| dc.contributor.author | Krause, Karoline | |
| dc.contributor.author | Gimenez- Arnau, Ana M. | |
| dc.contributor.author | Thomsen, Simon Francis | |
| dc.contributor.author | Conlon, Niall | |
| dc.contributor.author | Marsland, Alexander | |
| dc.contributor.author | Ateş, Can | |
| dc.date.accessioned | 2021-07-05T06:36:56Z | |
| dc.date.available | 2021-07-05T06:36:56Z | |
| dc.date.issued | 2021 | |
| dc.department | Tıp Fakültesi | |
| dc.description | *Ateş, Can ( Aksaray, Yazar ) | |
| dc.description.abstract | SciVal Topics Funding details Abstract Background: Chronic urticaria (CU) predominantly affects women, and sex hormones can modulate disease activity in female CU patients. As of now, the impact of pregnancy on CU is largely unknown. Aim: To analyze the course and features of CU during and after pregnancy. Patients and methods: PREG-CU is an international, multicenter study of the Urticaria Centers of Reference and Excellence (UCARE) network. Data were collected via a 47-item questionnaire completed by CU patients, who became pregnant within the last 3 years. Results: A total of 288 pregnancies of 288 CU patients from 13 countries were analyzed (mean age at pregnancy: 32.1 ± 6.1 years, duration of CU: 84.9 ± 74.5 months; CSU 66.9%, CSU + CIndU 20.3%, CIndU 12.8%).During pregnancy, 51.1% of patients rated their CU as improved, 28.9% as worse, and 20.0% as unchanged.CU exacerbations most commonly occurred exclusively during the third trimester (in 34 of 124 patients; 27.6%) or the first (28 of 124; 22.8%). The risk factors for worsening of CU during pregnancy were having mild disease and no angioedema before pregnancy, not taking treatment before pregnancy, CIndU, CU worsening during a previous pregnancy, treatment during pregnancy, and stress as a driver of exacerbations. After giving birth, urticaria disease activity remained unchanged in 43.8% of CU patients, whereas 37.4% and 18.1% experienced worsening and improvement, respectively. Conclusions: These results demonstrate the complex impact of pregnancy on the course of CU and help to better counsel patients who want to become pregnant and to manage CU during pregnancy. | |
| dc.identifier.doi | 10.1111/all.14950 | |
| dc.identifier.endpage | - | en_US |
| dc.identifier.issn | 0105-4538 | |
| dc.identifier.issue | - | en_US |
| dc.identifier.pmid | 34022061 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | - | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.1111/all.14950 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/8305 | |
| dc.identifier.volume | - | en_US |
| dc.identifier.wos | WOS:000660479300001 | |
| dc.identifier.wosquality | Q1 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Blackwell Publishing Ltd | |
| dc.relation.ispartof | Allergy: European Journal of Allergy and Clinical Immunology | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | Breastfeeding | |
| dc.subject | Disease Activity | |
| dc.subject | Hormones | |
| dc.subject | Pregnancy | |
| dc.subject | Urticaria | |
| dc.title | Effects of pregnancy on chronic urticaria: Results of the PREG-CU UCARE study | |
| dc.type | Article |
