Antisense oligonucleotide delivery to cancer cell lines for the treatment of different cancer types
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amphiphilic poly(3-hydroxylalkanoate) (PHA) copolymers find interesting applications in drug delivery. The aim of this study was to prepare nucleic acid adsorbed on (PHB-b-PEG-NH2) nanoparticle platform for gene delivery. For this purpose, PHB-b-PEG-NH2 block copolymers were synthesized via transesterification reactions. The copolymers obtained were characterized by Proton Nuclear Magnetic Resonance (H-1-NMR), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) techniques. The cytotoxic, apoptotic and necrotic effects of these nanoparticles in the MDA 231 human breast cancer cell, the A549 human lung cancer cell and the L929 fibroblast cell lines were also investigated.
Açıklama
Anahtar Kelimeler
Antisense Oligonucleotide, Fibroblast Cells, Human Breast Cancer Cells, Human Lung Cancer Cells, PHB-PEG Bock Copolymer, PHB-PEG Nanoparticle
Kaynak
Artificial Cells Nanomedicine And Biotechnology
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
44
Sayı
8
