Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy

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dc.contributor.authorYıldız, Mustafa Onur
dc.contributor.authorÇelik, Hamit
dc.contributor.authorÇağlayan, Cüneyt
dc.contributor.authorKandemir, Fatih Mehmet
dc.contributor.authorGür, Cihan
dc.contributor.authorBayav, İbrahim
dc.contributor.authorGenç, Aydın
dc.contributor.authorKandemir, Özge
dc.date.accessioned2022-04-14T10:36:27Z
dc.date.available2022-04-14T10:36:27Z
dc.date.issued2022
dc.departmentTıp Fakültesi
dc.description.abstractFluoride is an element with toxic properties and has been proven to have some adverse effects on many soft tissues, including brain tissue. This study aims to evaluate the protective effects of hesperidin on sodium fluoride (NaF)-induced neurotoxicity in rats by biochemical and molecular methods. The animals were randomly divided into five groups of seven rats each as Control, hesperidin, NaF (600 ppm), NaF + hesperidin (100mg/kg, b.w.), and NaF + hesperidin (200mg/kg, b.w.), respectively; orally for two weeks. Hesperidin reduced lipid peroxidation and increased activities of SOD, CAT and GPx and levels of GSH in NaF-induced brain tissue. Hesperidin also showed anti-inflammatory and anti-autophagic effects by decreasing levels of NF-?B, IL-1B, TNF-?, Beclin-1, LC3A, and LC3B in NaF-induced brain tissue. Moreover, hesperidin was able to down-regulate the mRNA transcript levels of apoptosis and endoplasmic reticulum stress markers such as caspase-3, Bax, Bcl-2, PERK, IRE1, ATF6, and GRP78 in NaF-induced neurotoxicity. Hesperidin also reduced the adverse effects caused by NaF by modulating the PI3K/Akt/mTOR signaling pathway. These results demonstrate that hesperidin exhibits neuroprotective effects against NaF-induced neurotoxicity in rats by ameliorating inflammation, apoptosis, autophagy, and endoplasmic reticulum stress.
dc.identifier.doi10.1016/j.neuro.2022.04.002.
dc.identifier.endpage-en_US
dc.identifier.issue-en_US
dc.identifier.pmid35413380
dc.identifier.scopusqualityQ2
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1016/j.neuro.2022.04.002.
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9294
dc.identifier.volume-en_US
dc.identifier.wosWOS:000793681700002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNeurotoxicology
dc.relation.ispartofNeurotoxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectAutophagy
dc.subjectEndoplasmic Reticulum Stress
dc.subjectHesperidin
dc.subjectNeurotoxicity
dc.subjectSodium Fluoride
dc.titleNeuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy
dc.typeArticle

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