DNA interaction, antitumor and antimicrobial activities of three-dimensional chitosan ring produced from the body segments of a diplopod

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dc.authoridSargin, Idris -- 0000-0003-3785-9575; Mickevicius, Saulius -- 0000-0002-2095-1060; Erdonmez, Demet -- 0000-0002-5331-2206; Tan, Gamze -- 0000-0002-2755-1756; AKYUZ YILMAZ, Bahar -- 0000-0001-9760-9856; Kaya, Murat -- 0000-0001-6954-2703
dc.contributor.authorKaya, Murat
dc.contributor.authorAkyüz, Bahar
dc.contributor.authorBulut, Esra
dc.contributor.authorSargın, İdris
dc.contributor.authorTan, Gamze
dc.contributor.authorErdönmez, Demet
dc.contributor.authorMaheta, Mansi
dc.contributor.authorSatkauskas, Saulius
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:43Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:43Z
dc.date.issued2016
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractCommercially available chitins and the chitin isolated from mushrooms, insect cuticles, shells of shrimp, crab and crayfish reported in the literature are in forms of powder, flake or granule. Three-dimensional chitins have been only known from the sponges but still three-dimensional chitosan has not been reported yet. In this study, we produced three-dimensional chitin and chitosan rings from the body segments of a diplopod species (Julus terrestris). Obtained chitin and chitosan rings were characterized (by FT-IR, SEM, TGA, XRD, dilute solution viscometry and EA) and compared with commercial chitin and chitosan. The interactions with plasmid DNA was studied at varying concentrations of chitosan (0.04, 0.4 and 4 mg/mL). Antitumor activity tests were conducted (L929 and HeLa), low cytotoxicity and high antiproliferative activity was observed. Antimicrobial activities of J. terrestris chitosan were investigated on twelve microorganisms and maximum inhibition (15.6 +/- 1.154 mm) was recorded for common human pathogen Staphylococcus aureus. (C) 2016 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.carbpol.2016.03.033
dc.identifier.endpage89en_US
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.pmid27112853
dc.identifier.scopusqualityQ1
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2016.03.033
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5916
dc.identifier.volume146en_US
dc.identifier.wosWOS:000375110500010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevıer Scı Ltd
dc.relation.ispartofCarbohydrate Polymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMillipede
dc.subjectChitin
dc.subjectBiopolymer
dc.subjectCytotoxicity
dc.subjectHeLa Cell Line
dc.subjectAntibacterial
dc.titleDNA interaction, antitumor and antimicrobial activities of three-dimensional chitosan ring produced from the body segments of a diplopod
dc.typeArticle

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