Evaluation of both expression and serum protein levels of caspase-8 and mitogen-activated protein kinase 1 genes in patients with different severities of COVID-19 infection

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dc.authorid0000-0002-7163-4882
dc.contributor.authorAcat, Murat
dc.contributor.authorYıldız Gülhan, Pınar
dc.contributor.authorEröz, Recep
dc.contributor.authorErtınmaz Özkan, Ayşegül
dc.contributor.authorKoca, Oğuzhan
dc.contributor.authorÇınar, Caner
dc.date.accessioned2023-02-24T06:29:54Z
dc.date.available2023-02-24T06:29:54Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractAim: The current study aimed to evaluate the effects of caspase-8 (CASP8) and mitogen-activated protein kinase 1 (MAPK1) gene expression levels and their products on preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: A total of 40 patients (men, 15 [37.5%]; women, 25 [62.5%]) with COVID-19 infection were included in the current study. The patients were divided into four main groups based on disease severity: mild (n = 7), moderate (n = 10), severe (n = 14), and critical (n = 9). Individuals aged < 18 years and pregnant women were excluded. Patients were classified according to the World Health Organization (WHO) classification system (WHO/2019-nCoV/clinical/2021.1). Results: Considering all groups, statistically significant differences were detected among all groups for both CASP82???Ct (p = 0.006) and MAPK1 2???Ct values (p = 0.015). Moreover, statistically significant differences were detected between mild and moderate (p = 0.013), moderate and critical (p = 0.018), and severe and critical (p = 0.023) groups for lymphocytes. Conclusion: The CASP8/MAPK1 expression levels and/or its products are essential in preventing injury caused by COVID-19 infection. They play crucial roles in maintaining cellular homeostasis and viability. Furthermore, CASP8/MAPK1 levels can provide information about disease severity.
dc.identifier.doi10.1007/s11033-023-08244-4
dc.identifier.issn0301-4851
dc.identifier.pmid36708447
dc.identifier.scopusqualityQ2
dc.identifier.urihttps:/dx.doi.org/10.1007/s11033-023-08244-4
dc.identifier.urihttps://hdl.handle.net/20.500.12451/10285
dc.identifier.wosWOS:000921163100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Science and Business Media B.V.
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCASP8 Gene
dc.subjectCellular Homeostasis
dc.subjectMAPK1
dc.subjectSARS-CoV-2
dc.titleEvaluation of both expression and serum protein levels of caspase-8 and mitogen-activated protein kinase 1 genes in patients with different severities of COVID-19 infection
dc.typeArticle

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