Phytochemical Characterization and Assessment of Antioxidant and Anti-Alzheimer Effects of Algerian Seseli Tortuosum

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dc.contributor.authorSlimani, Abdelkader
dc.contributor.authorAkkal, Wail
dc.contributor.authorBenmekhbi, Ahmed Acheraf
dc.contributor.authorMosbah, Asma
dc.contributor.authorÇakmak, Yavuz Selim
dc.contributor.authorLefahal, Mostefa
dc.contributor.authorBousetla, Ahlem
dc.contributor.authorBensouici, Chawki
dc.contributor.authorLaouer, Hocine
dc.contributor.authorAkkal, Salah
dc.contributor.authorNieto, Gema
dc.date.accessioned2025-04-15T13:23:55Z
dc.date.available2025-04-15T13:23:55Z
dc.date.issued2024
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractHPLC analysis, phytochemical screening, thin layer chromatography, polyphenols and flavonoid contents were conducted to determine the bioactive contents of the Algerian Seseli tortuosum plant. Antioxidant activity was tested using DPPH and ABTS scavenging assays, reducing power, phenanthroline and silver nanoparticle (SNP) assays. The anti-Alzheimer's activity of extracts was also performed invitro and in silico. Phytochemical analysis highlighted the richness ofthe extracts in terms of coumarins, terpenoids and quercetin. The quantitative determination of total polyphenols and flavonoids showed that the highest amounts occurredinthe dichloromethane (DCME) and methanolic (MeOH) extracts. The antioxidant activities indicated a moderate potential. Compared with galantamine, DCME had a significantly greater anti-Alzheimer effect on BChE(CI50=9.14 +/- 1.74 mu g/ml and 34.75 +/- 1.99 mu g/ml respectively). An in silicostudy of anti-Alzheimer activity revealed a significant effect of quercetin(-30,13KJ/mol). Conclusion: This study demonstrated the richness of the phytochemical components of seseli tortuosum,which are responsible for several biological properties, mainly their anti-Alzheimer potential.
dc.identifier.doi10.1002/cbdv.202400482
dc.identifier.issn1612-1872 / 1612-1880
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85209778845
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://dx.doi.org/10.1002/cbdv.202400482
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13050
dc.identifier.volume22
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÇakmak, Yavuz Selim
dc.language.isotr
dc.publisherWiley
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant Activity
dc.subjectAnti-Alzheimer Activity
dc.subjectIn Silico Study
dc.subjectPhytochemical Analysis
dc.subjectSeseli Trotuosum
dc.titlePhytochemical Characterization and Assessment of Antioxidant and Anti-Alzheimer Effects of Algerian Seseli Tortuosum
dc.typeArticle

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