Systemic retinoids and scar dehiscence

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dc.contributor.authorAksoy, Hasan Mete
dc.contributor.authorAksoy, Berna
dc.contributor.authorÇalıkoğlu, Emel
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:16:31Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:16:31Z
dc.date.issued2019
dc.departmentTıp Fakültesi
dc.description.abstractSystemic retinoids such as isotretinoin and acitretin are associated with numerous side effects but are therapeutically valuable in dermatological practice. Several studies have reported the wound-healing effects of treatment with concurrent systemic retinoids in addition to surgical treatments. Herein, we describe two patients with scar dehiscence that developed after initiation of systemic retinoid treatment following cutaneous surgery. In Case 1, isotretinoin was thought to decrease collagen production to a greater degree than did degradation during the wound remodeling phase, which resulted in wound dehiscence. In Case 2, acitretin was thought to decrease fibroblast proliferation and collagen production during the proliferation phase of wound healing, which resulted in wound dehiscence. Based on the two presented cases, it is advisable to postpone systemic retinoid treatment for 6 months to 1 year following cutaneous surgery, located especially in cosmetically important sites.
dc.identifier.doi10.4103/ijd.IJD_148_18
dc.identifier.endpage70en_US
dc.identifier.issn0019-5154
dc.identifier.issn1998-3611
dc.identifier.issue1en_US
dc.identifier.pmid30745640
dc.identifier.scopusqualityQ3
dc.identifier.startpage68en_US
dc.identifier.urihttps://doi.org/10.4103/ijd.IJD_148_18
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4609
dc.identifier.volume64en_US
dc.identifier.wosWOS:000455771700014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcitretin
dc.subjectDehiscence
dc.subjectIsotretinoin
dc.subjectRetinoid
dc.subjectScar
dc.subjectWound Healing
dc.titleSystemic retinoids and scar dehiscence
dc.typeArticle

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