Alterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide

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dc.contributor.authorAcar, Ümit
dc.contributor.authorİnanan, Burak Evren
dc.contributor.authorNavruz, Fahriye Zemheri
dc.contributor.authorYılmaz, Sevdan
dc.date.accessioned2021-12-07T07:41:01Z
dc.date.available2021-12-07T07:41:01Z
dc.date.issued2021
dc.departmentVeteriner Fakültesi
dc.description.abstractIn this study, effects of different concentrations (0, 5, 10, 20, 30, and 40 mg/L) of glyphosate-based herbicide (GBH) on Nile tilapia (Oreochromis nikticus) were investigated after a 14-day of exposure. After determination of LC50 value, effects of GBH on hematological and serum biochemical parameters in blood samples, DNA damage, lipid pemxidation and catalase activity in liver tissues, expression levels of antioxidant enzyme-related genes (SOD, CAT, GPx, and GST) and immune-related genes (TGF-beta, TGF-alpha and IL1-beta) were evaluated. The LC50 value has been found as 44.4 mg/L for GBH. GBH exposure at all concentrations caused alterations in blood parameters. GBH induced oxidative stress in liver and DNA damage in blood. Antioxidant enzyme-related genes were significantly up-regulated to suppress oxidative stress. On the other hand, the expression levels of immunerelated genes decreased in fish exposure to particularly >= 20 mg/L GBH.
dc.identifier.doi10.1016/j.cbpc.2021.109147
dc.identifier.endpage-en_US
dc.identifier.issue--en_US
dc.identifier.pmid34332143
dc.identifier.scopusqualityN/A
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1016/j.cbpc.2021.109147
dc.identifier.urihttps://hdl.handle.net/20.500.12451/8876
dc.identifier.volume249en_US
dc.identifier.wosWOS:000693443600005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofComparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectKeywords
dc.subjectGlyphosate
dc.subjectNile Tilapia (Oreochromis niloticus
dc.subjectDNA Damage
dc.subjectGene Expression
dc.subjectOxidative Stress
dc.titleAlterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide
dc.typeArticle

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