Serum nerve growth factor (NGF) levels in children with attention deficit/hyperactivity disorder (ADHD)

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dc.authoridKARA, Mehmet -- 0000-0002-4287-5433; KARA, Mehmet -- 0000-0002-4287-5433; Goker, Zeynep -- 0000-0002-6489-3800
dc.contributor.authorGuney, Esra
dc.contributor.authorCeylan, Mehmet Fatih
dc.contributor.authorKara, Mehmet
dc.contributor.authorTekin, Neslihan
dc.contributor.authorGöker, Zeynep
dc.contributor.authorŞenses Dinç, Gülser
dc.contributor.authorÖztürk, Önder
dc.contributor.authorEker, Sevda
dc.contributor.authorKızılgün, Murat
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:28Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:28Z
dc.date.issued2014
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractAttention deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurobehavioral disorder of childhood. The etiopathogeny of ADHD has not been totally defined. Recent reports have suggested a pathophysiological role of neurotrophins in ADHD. In this study, we evaluated serum levels of nerve growth factor (NGF) in patients with ADHD. The sample population consisted of 44 child or adolescent patients diagnosed with ADHD according to DSM-IV criteria; 36 healthy subjects were included in the study as controls. Venous blood samples were collected, and NGF levels were measured. The mean serum NGF levels of the ADHD patients were significantly higher than those of the controls. Age and gender of the patients were not correlated with serum NGF levels. There were no significant differences in NGF levels among the combined and predominantly inattentive subtypes of ADHD. Our study suggests that there are higher levels of serum NGF in drug naive ADHD patients, and that increased levels of NGF might have an important role in the pathophysiology of ADHD.
dc.identifier.doi10.1016/j.neulet.2013.12.026
dc.identifier.endpage111en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid24361544
dc.identifier.scopusqualityQ2
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2013.12.026
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5870
dc.identifier.volume560en_US
dc.identifier.wosWOS:000331022700022
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ltd.
dc.relation.ispartofNEUROSCIENCE LETTERS
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectADHD
dc.subjectNGF
dc.subjectNerve Growth Factor
dc.subjectNeurodevelopment
dc.titleSerum nerve growth factor (NGF) levels in children with attention deficit/hyperactivity disorder (ADHD)
dc.typeArticle

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