Serum netrin-1 levels at presentation and delayed neurological sequelae in unintentional carbon monoxide poisoning

Simple item page
dc.contributor.authorKokulu, Kamil
dc.contributor.authorMutlu, Hüseyin
dc.contributor.authorSert, Ekrem Taha
dc.date.accessioned2020-04-16T06:07:09Z
dc.date.available2020-04-16T06:07:09Z
dc.date.issued2020
dc.departmentTıp Fakültesi
dc.description*Mutlu, Hüseyin ( Aksaray, Yazar ) *Sert, Ekrem Taha ( Aksaray, Yazar )
dc.description.abstractObjectives: The early identification of patients with a high risk of developing delayed neurological sequelae (DNS) can improve the quality of care in carbon monoxide (CO) poisoning cases. The aim of this study is to investigate whether the serum netrin-1 levels measured at presentation to the emergency department (ED) predicted the development of DNS after acute CO intoxication. Methods: This prospective observational study was conducted between 1 August 2018 and 31 July 2019 in a single tertiary hospital. The patients with acute CO intoxication and serum netrin-1 levels measured at the time of ED presentation were included in the study. All patients were followed up for six weeks regarding the development of DNS. The patients were divided into two groups, including those who developed DNS (DNS group) and those who did not (non-DNS group). Results: A total of 183 patients were included in the study, and 54 (29.5%) developed DNS. The median serum netrin-1 level at ED presentation was significantly lower in the DNS group (391.5 pg/mL [263.0–550.5]) than in the non-DNS group (626.0 pg/mL [505.9–755.6]) (p <.001). Multivariate analysis revealed that a low serum netrin-1 level (adjusted odds ratio [AOR]: 8.02, 95% CI: 2.45–26.20), low Glasgow coma scale (GCS) score at ED presentation (AOR: 0.81, 95% CI: 0.68–0.97), long CO exposure time (AOR: 1.96, 95% CI: 1.49–2.56), and the presence of acute brain lesions (AOR: 8.24, 95% CI: 2.37–28.58) on diffusion-weighted imaging were independent predictors of DNS. Serum netrin-1 levels less than 432 pg/mL predicted the development of DNS with a sensitivity of 68.5% (95% CI: 54.4%-80.5%) and a specificity of 86.0% (95% CI: 78.8%-91.5%). Conclusions: Low serum netrin-1 levels were significantly associated with the development of DNS. Therefore, serum netrin-1 at ED presentation can help identify patients at risk of developing DNS following discharge.
dc.identifier.doi10.1080/15563650.2020.1743302
dc.identifier.endpage-en_US
dc.identifier.issn1556-3650
dc.identifier.issue-en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1080/15563650.2020.1743302
dc.identifier.urihttps://hdl.handle.net/20.500.12451/7532
dc.identifier.volume-en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofClinical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbon Monoxide
dc.subjectDelayed Neurological Sequelae
dc.subjectNetrin-1
dc.subjectPoisoning
dc.titleSerum netrin-1 levels at presentation and delayed neurological sequelae in unintentional carbon monoxide poisoning
dc.typeArticle

Files

License bundle
Now showing 1 - 1 of 1
[ X ]
Name:
license.txt
Size:
1.44 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu