Antipsychotic agents screened as human carbonic anhydrase I and II inhibitors

Basit Öğe Kaydı
dc.contributor.authorErzengin, Mahmut
dc.contributor.authorBilen, Çiğdem
dc.contributor.authorErgün, Adem
dc.contributor.authorGencer, Nahit
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:06Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:06Z
dc.date.issued2014
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe antipsychotic drugs currently used to treat schizophrenia can be divided into two distinct classes, typical and atypical antipsychotics. Many drug molecules are enzyme inhibitors that bind reversibly or irreversibly to their target through intermolecular interactions. That's why enzyme inhibition studies are an important issue for drug design and biochemical applications. In this study, in vitro inhibition effect of some antipsychotic drugs on the purified carbonic anhydrase (CA) I and II isoenzymes were investigated by using CO2 as a substrate. CA I and II were purified from human erythrocytes by a simple one step procedure using Sepharose 4B-L-tyrosine-sulfonamide affinity column. The results showed that all the drugs inhibited the cytosolic carbonic anhydrases enzyme activity in a concentration-dependent fashion. Among the studied drugs, aripiprazole and pramipexole were found to be the most active one for hCA I (IC50: 3.64 and 5.37 mu M) and hCA II (IC50: 4.16 and 4.81 mu M) activity, respectively.
dc.identifier.doi10.3109/13813455.2013.863359
dc.identifier.endpage33en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue1en_US
dc.identifier.pmid24289818
dc.identifier.scopusqualityQ1
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.3109/13813455.2013.863359
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5985
dc.identifier.volume120en_US
dc.identifier.wosWOS:000334916900004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntipsychotic Drugs
dc.subjectCarbonic Anhydrase
dc.subjectInhibition
dc.subjectPurification
dc.titleAntipsychotic agents screened as human carbonic anhydrase I and II inhibitors
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
erzengin-mahmut-2014.pdf
Boyut:
550.28 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu