The effects of levamisole and albendazole on spermatological parameters, testosterone levels, and sperm DNA damage in Saanen bucks

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dc.authorid0000-0001-8256-7868
dc.authorid0000-0001-5268-5046
dc.authorid0000-0003-3780-4021
dc.authorid0000-0003-1866-932X
dc.contributor.authorYücel, Ufuk Mercan
dc.contributor.authorKoşal, Volkan
dc.contributor.authorTaşpınar, Filiz
dc.contributor.authorUslu, Barış Atalay
dc.date.accessioned2021-12-07T06:38:40Z
dc.date.available2021-12-07T06:38:40Z
dc.date.issued2021
dc.departmentTıp Fakültesi
dc.description.abstractThis study aimed to investigate the effect of levamisole and albendazole on spermatological parameters, testosterone levels, and sperm DNA damage in Saanen bucks. For this purpose, twenty-four Saanen bucks were divided into three groups as control, levamisole, and albendazole administration group. The control group received only water (20 ml, oral), the levamisole group received 7.5 mg/kg of levamisole (2 oral tablets once daily for 2 days) + water (20 ml, oral), and the albendazole group received 7.5 mg/kg of albendazole (1 oral tablet) + water (20 ml, oral). Semen and blood samples were collected from all animals, both before drug application (day 0) and within a 2-day interval after drug application between day 1 (day of the treatment) and day 11. Spermatological parameters were evaluated immediately after collection. Testosterone levels were also measured from the blood samples with ELISA. Sperm DNA damage was determined with comet assay. The present research showed that especially albendazole administration decreased spermatological parameters and levamisole administration decreased testosterone levels. Significant sperm DNA damage was seen after both albendazole and levamisole administration. As a result, albendazole and levamisole administration should be used carefully on Saanen bucks, especially during the breeding season.
dc.identifier.doi10.1007/s11250-021-02895-w
dc.identifier.endpage-en_US
dc.identifier.issn0049-4747
dc.identifier.issue5en_US
dc.identifier.pmid34545434
dc.identifier.scopusqualityQ2
dc.identifier.urihttps:/dx.doi.org/10.1007/s11250-021-02895-w
dc.identifier.urihttps://hdl.handle.net/20.500.12451/8874
dc.identifier.volume53en_US
dc.identifier.wosWOS:000698126900007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Science and Business Media B.V.
dc.relation.ispartofTropical Animal Health and Production
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlbendazole
dc.subjectLevamisole
dc.subjectSaanen Bucks
dc.subjectSperm DNA Damage
dc.subjectSpermatological Parameters
dc.subjectTestosterone
dc.titleThe effects of levamisole and albendazole on spermatological parameters, testosterone levels, and sperm DNA damage in Saanen bucks
dc.typeArticle

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