Thiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry disease

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dc.contributor.authorErdal, Hüseyin
dc.contributor.authorTurgut, Faruk
dc.date.accessioned2024-04-19T12:35:36Z
dc.date.available2024-04-19T12:35:36Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractThis is the first study to show both dynamic thiol-disulfide balance and oxidative stress levels in patients with Fabry disease (FD). This prospective study consists of 30 FD patients and 30 healthy controls. Thiol and disulfide values of the study groups were evaluated using a new, cost-effective and fully automatic colorimetric method. A total of 60 subjects were included in the study. A statistically significant difference was found between the patient and control groups for native and total thiol levels (p < 0.001). In addition, disulfide levels were significantly higher in FD patients compared with the control group (p < 0.003). Native thiol levels showed significantly negative correlation with lysosomal globotriaosylceramide, total oxidant status (TOS), and oxidative stress index (OSI) levels. In addition, a positive correlation was found between disulfide/natural thiol and disulfide/total thiol ratios and TOS, OSI, and blood urea nitrogen. We found total antioxidant status levels were lower in the patient group compared to the control group, while TOS and OSI levels were higher and were statistically significant. This study highlights for the first time a novel, cost-effective and fully automated measurement of thiol-disulfide levels in patients with FD.
dc.identifier.doi10.1177/10815589231191966
dc.identifier.endpage870en_US
dc.identifier.issn1081-5589
dc.identifier.issue8en_US
dc.identifier.pmid37485970
dc.identifier.scopusqualityQ2
dc.identifier.startpage865en_US
dc.identifier.urihttps:/dx.doi.org10.1177/10815589231191966
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11666
dc.identifier.volume71en_US
dc.identifier.wosWOS:001098990000010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE Publications Inc.
dc.relation.ispartofJournal of Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFabry Disease
dc.subjectFree Radicals Thiol-disulfide Homeostasis
dc.subjectOxidative Stress
dc.subjectReactive Oxygen Species
dc.titleThiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry disease
dc.typeArticle

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