Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
| dc.authorid | 0000-0002-8490-2479 | |
| dc.contributor.author | Kızıl, Hamit Emre | |
| dc.contributor.author | Çağlayan, Cüneyt | |
| dc.contributor.author | Darandelioğlu, Ekrem | |
| dc.contributor.author | Ayna, Adnan | |
| dc.contributor.author | Gür, Cihan | |
| dc.contributor.author | Kandemir, Fatih Mehmet | |
| dc.contributor.author | Küçükler, Sefa | |
| dc.date.accessioned | 2023-02-27T06:58:18Z | |
| dc.date.available | 2023-02-27T06:58:18Z | |
| dc.date.issued | 2023 | |
| dc.department | Tıp Fakültesi | |
| dc.description.abstract | Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side effects of long-term MTX use. The present study unveils new confirmations as regards the remedial effects of morin on MTX-induced hepatocellular injury through regulation of oxidative stress, apoptosis and MAPK signaling. | |
| dc.identifier.doi | 10.1007/s11033-023-08286-8 | |
| dc.identifier.pmid | 36781607 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.uri | https:/dx.doi.org/10.1007/s11033-023-08286-8 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/10298 | |
| dc.identifier.wos | WOS:000930317000003 | |
| dc.identifier.wosquality | Q3 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Springer | |
| dc.relation.ispartof | Molecular Biology Reports | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Apoptosis | |
| dc.subject | Hepatotoxicity | |
| dc.subject | Methotrexate | |
| dc.subject | Morin | |
| dc.subject | Oxidative Stress | |
| dc.title | Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways | |
| dc.type | Article |
