Structural neuroimaging findings in migraine patients with restless legs syndrome

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dc.contributor.authorAldemir, Arzu
dc.contributor.authorYücel, Kaan
dc.contributor.authorGüven, Hayat
dc.contributor.authorKamaşak, Burcu
dc.contributor.authorDıllı, Alper
dc.contributor.authorAcer, Niyazi
dc.contributor.authorÇomo?lu, Selim Selçuk
dc.date.accessioned2021-06-16T11:20:50Z
dc.date.available2021-06-16T11:20:50Z
dc.date.issued2020
dc.departmentTıp Fakültesi
dc.description*Yücel, Kaan ( Aksaray, Yazar )
dc.description.abstractPurpose: One out of three migraine patients might have accompanying restless legs syndrome (RLS). In our study, we aimed to compare the volumes of the brain structures of migraineurs with and without RLS. Methods: We had 37 female patients with migraine and 17 females as the control group. Nineteen migraineurs had no RLS (RLS0) and 18 migraineurs had comorbidity of RLS (RLS1). The volumes of the brain structures were obtained by manual measurements, volBrain, and voxel-based morphometry (VBM). Manually, we measured caudate and putamen volumes. We used age, years of education, depression, anxiety scores, and total intracranial volume as covariates. Results: According to VBM analyses, the volumes of the left superior occipital gyrus and precuneus were increased, and the substantia nigra and cuneus were decreased in the RLS1 group compared with the RLS0 group. RLS1 patients had larger superior temporal gyrus, Brodmann area 38, and left insula, and RLS0 patients had larger Brodmann area 22, right superior temporal gyrus, and Heschl gyrus compared with controls. Migraine and RLS0 patients had a smaller corpus callosum anteriorly, whereas RLS1 patients had a smaller splenium. Caudate volumes were larger in migraine patients via the three techniques. There was a positive relation between the caudate and putamen volumes and attack frequency. Conclusions: Comorbidity of RLS might be a confounding factor in structural neuroimaging studies in migraine. Deficits in the visual network seem to be related to accompanying RLS; deficits in the auditory network are particularly related to migraine.
dc.identifier.doi10.1007/s00234-020-02451-7
dc.identifier.endpage1313en_US
dc.identifier.issn0028-3940
dc.identifier.issue10en_US
dc.identifier.pmid32488307
dc.identifier.scopusqualityQ2
dc.identifier.startpage1301en_US
dc.identifier.urihttps:/dx.doi.org/10.1007/s00234-020-02451-7
dc.identifier.urihttps://hdl.handle.net/20.500.12451/8122
dc.identifier.volume62en_US
dc.identifier.wosWOS:000537346400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofNeuroradiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectComorbidity
dc.subjectMigraine
dc.subjectRestless Legs Syndrome
dc.subjectVolumetric Magnetic Resonance Imaging
dc.subjectVoxel-based Morphometry
dc.titleStructural neuroimaging findings in migraine patients with restless legs syndrome
dc.typeArticle

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