An immunohistochemical study on the evaluation of mast cell, interleukin 17 and interleukin 1? profile in contagious caprine pleuropneumonia

dc.contributor.author:Karataş , Özhan
dc.contributor.authorAkçakavak, Gökhan
dc.date.accessioned2024-11-13T12:04:19Z
dc.date.available2024-11-13T12:04:19Z
dc.date.issued2024
dc.departmentVeteriner Fakültesi
dc.description.abstractContagious caprine pleuropneumonia (CCPP) in goats is defined as a highly contagious and rapidly spreading mycoplasmal disease that is now among the leading causes of major economic losses on many continents (Asia, Africa and the Middle East). In this study, we aimed to evaluate immunohistochemically mast cells (MCs) profile and local interleukin (IL)-17 and IL-1? protein expressions in naturally infected CCPP according to the course of the inflammation (peracute-acute, subacute-chronic). The material of the study consisted of 40 naturally infected CCPP and 6 healthy control goat lung tissues. Appropriate samples were taken from the necropsied goats and subjected to histopathological and immunohistochemical examination. In the histopathological examination of the samples, it was determined that 29 samples had a peracute-acute course and 11 had a subacute-chronic course. In immuno-histochemical examination, MC profile and local IL-17 and IL-1? protein expressions were evaluated in the peracute-acute and subacute-chronic course. Immunohistochemically, significant increases in MC number, local IL-17 and IL-1? scores were detected in the peracute-acute course compared to the control group. There were significant decreases in the relevant scores in the subacute-chronic course compared to the peracute-acute course. Current findings indicated that MC, IL-17, and IL-1? expressions played important roles in the pathogenesis of infection in naturally infected CCPP, especially in the peracute-acute course.
dc.identifier.doi10.30466/vrf.2024.2023580.4184
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3
dc.identifier.urihttps:/dx.doi.org/10.30466/vrf.2024.2023580.4184
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12624
dc.identifier.volume15en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUrmia University - Faculty of Veterinary Medicine
dc.relation.ispartofVeterinary Research Forum
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCaprine
dc.subjectImmunohistochemistry
dc.subjectInterleukin-17
dc.subjectInterleukin-1?
dc.subjectMast Cell
dc.titleAn immunohistochemical study on the evaluation of mast cell, interleukin 17 and interleukin 1? profile in contagious caprine pleuropneumonia
dc.typeArticle

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