Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro-inflammation

Basit Öğe Kaydı
dc.contributor.authorYardım, Ahmet
dc.contributor.authorGür, Cihan
dc.contributor.authorÇomaklı, Selim
dc.contributor.authorÖzdemir, Selçuk
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorÇelik, Hamit
dc.contributor.authorKandemir, Fatih Mehmet
dc.date.accessioned2022-02-23T09:57:55Z
dc.date.available2022-02-23T09:57:55Z
dc.date.issued2022
dc.departmentTıp Fakültesi
dc.description.abstractBortezomib (BTZ), a proteasome inhibitor, causes dose-limiting peripheral neuropathy in humans. Berberine (BBR), which has various biological and pharmacological properties, is known to have neuroprotective properties. The possible protective effects of BBR on peripheral neuropathy caused by BTZ were investigated in this study. For this purpose, BTZ was intraperitoneally given to Sprague dawley rats on the 1 st, 3rd, 5th, and 7th days with a cumulative dose of 0.8 mg/kg. Moreover, animals were orally administered 50 or 100 mg/kg BBR daily from day 1 to day 10. As a result of the analyzes performed on the sciatic nerve and spinal cord, it was observed that MDA levels and NRF-2, HO-1, NQO1, GCLC and GCLM mRNA transcript levels increased due to oxidative stress caused by BTZ, and the levels of these markers decreased after BBR administration. Also, it was determined that SOD, CAT, GPx and GSH levels increased after BBR treatment. It was observed that BTZ caused inflammation by triggering NF-?B, TNF-?, IL-1? and IL-6 cytokines, on the other hand, with BBR treatment, these cytokines were suppressed and inflammation was alleviated. In addition, it was determined that the expressions of RAGE, STAT3, NLRP3 and TLR4, which have important roles in inflammation, increased with BTZ administration, but BBR suppressed the expressions of these genes. It was determined that the expressions of SIRT1, which plays an important role in neuropathic pain, and CREB-LI neurons, which has an active role in neurite outgrowth and survival, decreased with BTZ administration. It was observed that GFAP levels increased with BTZ administration and decreased with BBR administration. Given all the findings, it was concluded that BBR exhibits protective qualities in the sciatic nerve and spinal cord induced by BTZ.
dc.identifier.doi10.1016/j.neuro.2022.01.011
dc.identifier.endpage139en_US
dc.identifier.issn0161-813X
dc.identifier.issue-en_US
dc.identifier.pmid35121005
dc.identifier.scopusqualityQ2
dc.identifier.startpage127en_US
dc.identifier.urihttps:/dx.doi.org/10.1016/j.neuro.2022.01.011
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9210
dc.identifier.volume89en_US
dc.identifier.wosWOS:000784295800003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroToxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBerberine
dc.subjectBortezomib
dc.subjectNeuro-inflammation
dc.subjectOxidative Stress
dc.subjectSciatic Nerve
dc.subjectSpinal Cord
dc.titleInvestigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro-inflammation
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
yardim-ahmet-2022.pdf
Boyut:
10.59 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu