The mutagenic, antimutagenic and antioxidant properties of Hypericum lydium

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dc.contributor.authorBoran, Rukiye
dc.contributor.authorUğur, Aysel
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:30:10Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:30:10Z
dc.date.issued2017
dc.departmentSağlık Hizmetleri Meslek Yüksekokulu
dc.description.abstractContext: There is a growing market demand for Hypericum sp., a pharmacologically active plant that has been traditionally used to treat various ailments. However, there have been limited studies on the extract or essential oil of Hypericum lydium Boiss (Hypericaceae). Objective: This study investigates for the first time the antioxidant, mutagenic and antimutagenic activity of an ethanol extract of H. lydium. Material and methods: Ethanol extract from aerial parts of H. lydium harvested from Turkey were tested for this mutagenic and antimutagenic activities (2.0-0.002 mg/plate) using Ames Salmonella/microsome test system. 4-Nitro-o-phenylenediamine (4-NPD) (3 mu g/plate) for the Salmonella typhimurium TA98 and sodium azide (NaN3) (8 mu g/plate) for the S. typhimurium TA100 were used as positive controls. The antioxidant activity, total antioxidant activity and phenolic constituent of the extract (2.0-0.002 mg/mL) was determined by the inhibition of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), beta-carotene-linoleic acid model and by means of Folin-Ciocalteu reagent, respectively. Results: The extract showed no sign of mutagenicity at the tested concentrations (0.002-2.0 mg/mL), and showed concentration-dependent antimutagenic activity against NaN3 and 4-NPD ranging from 26.8 to 81.5%. The extract was found to be an efficient scavenger of DPPH (IC50 0.165 +/- 0.23 mg/mL) and to inhibit beta-carotene-linoleic acid bleaching (IC50 0.39 +/- 0.11 mg/mL). Discussion and conclusion: These findings indicate ethanol extract of H. lydium to be a safe and effective agent that may be incorporated into new strategies for the prevention of cancer and mutagenesis.
dc.identifier.doi10.1080/13880209.2016.1242146
dc.identifier.endpage405en_US
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issue1en_US
dc.identifier.pmid27931153
dc.identifier.scopusqualityQ1
dc.identifier.startpage402en_US
dc.identifier.urihttps://doi.org/10.1080/13880209.2016.1242146
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6246
dc.identifier.volume55en_US
dc.identifier.wosWOS:000390846600044
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofPHARMACEUTICAL BIOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntimutagenicity
dc.subjectFree Radical Damage
dc.subjectNatural Products
dc.titleThe mutagenic, antimutagenic and antioxidant properties of Hypericum lydium
dc.typeArticle

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