Effect of local and systemic dimethylsulfoxide on peripheral nerve repair: A controlled randomized experimental study
| dc.contributor.author | Şanlı, Elif | |
| dc.contributor.author | Dinçel, Güngör Çağdaş | |
| dc.contributor.author | Umay, Ebru | |
| dc.date.accessioned | 2021-07-06T10:51:28Z | |
| dc.date.available | 2021-07-06T10:51:28Z | |
| dc.date.issued | 2021 | |
| dc.department | Eskil Meslek Yüksekokulu | |
| dc.description.abstract | Introduction: We investigated the possible beneficial effect of dimethylsulfoxide (DMSO) on peripheral nerve repair in rats. Methods: Seventy rats were divided into four groups: control, sham, DMSO-L, and DMSO-IP. Except in the control group, nerve repair was done at the right sciatic nerve. DMSO was administered locally and intraperitoneally for 12 weeks to the DMSO-L and DMSO-IP groups, respectively. No therapeutic agent was administered to the other groups. Nerve regeneration was assessed by behavioral, electrophysiological, histopathological, and immunohistochemical tests. Results: With the exception of S-100 protein expression, all results indicate that DMSO has a beneficial effect on peripheral nerve regeneration. Functional nerve recovery was notably more evident in the DMSO-L than in the DMSO-IP group. Under macroscopic examination, nerve scores of the regeneration area in the DMSO-L group was also better than in the others. Discussion: We believe that DMSO can improve peripheral nerve regeneration in rats. | |
| dc.identifier.doi | 10.1080/08941939.2019.1644403 | |
| dc.identifier.endpage | 465 | en_US |
| dc.identifier.issn | 0894-1939 | |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | 454 | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.1080/08941939.2019.1644403 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/8341 | |
| dc.identifier.volume | 34 | en_US |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Taylor and Francis Ltd. | |
| dc.relation.ispartof | Journal of Investigative Surgery | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Dimethylsulfoxide | |
| dc.subject | DMSO | |
| dc.subject | Muscle | |
| dc.subject | Nerve | |
| dc.subject | Neurotmesis | |
| dc.subject | Peripheral Nerve Injury | |
| dc.title | Effect of local and systemic dimethylsulfoxide on peripheral nerve repair: A controlled randomized experimental study | |
| dc.type | Article |
