Transplantation of limbal derived MSCs grown on contact lenses in dogs with dry eye syndrome - can stem cells help

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dc.contributor.authorBoztok Özgermen, Başak
dc.contributor.authorCan, Pınar
dc.contributor.authorSancak, İrem
dc.contributor.authorAkpınar, Eylül
dc.contributor.authorPınarlı, Ferda
dc.contributor.authorCeylan, Ahmet
dc.contributor.authorÖzen, Doğukan
dc.contributor.authorÖzen, Asuman
dc.date.accessioned2021-12-13T05:50:08Z
dc.date.available2021-12-13T05:50:08Z
dc.date.issued2021
dc.departmentVeteriner Fakültesi
dc.description.abstractKeratoconjunctivitis Sicca (KCS), also known as “dry eye syndrome”, is a common ocular disease in dogs, caused by inflammation of the lacrimal gland, resulting in decreased tear production. Efforts are being made to develop alternative therapies in order to prevent lifelong use of drugs for patients with KCS. Mesenchymal stem cells (MSCs) are known to be effective in the treatment of many immune-mediated diseases in human and animal models due to their immunoregulatory properties. The aim of this study was to transplant limbal mesenchymal stem cells (LMSCs) to the ocular surface on contact lenses and to evaluate the therapeutic effects of the LMSCs by clinical examination findings. The animals were randomly divided into study and control groups. The LMSC group (n = 10) received LMSCs (at least 2×106 cells) cultured on contact lenses. The conventional treatment group (n = 10) received artificial tears, topical 0.05% Cs A, and antibiotic eye drops, 3 times a day for 4 weeks. The Schirmer test, tear break-up time, impression cytology, Rose Bengal staining, and tear osmolarity were measured in all patients. The findings of the pre-treatment, two weeks and four weeks after the treatment, were evaluated statistically. In both groups, significant improvement was present compared to the pre-treatment findings. However, there was no significant difference between the groups. KCS treatment using LMSCs produced on contact lenses is promising, with its ease of application, non-immunogenic properties and single dose administration.
dc.identifier.doi10.24099/vet.arhiv.0951
dc.identifier.endpage358en_US
dc.identifier.issn0372-5480
dc.identifier.issn1331-8055
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage349en_US
dc.identifier.urihttps:/dx.doi.org/10.24099/vet.arhiv.0951
dc.identifier.urihttps://hdl.handle.net/20.500.12451/8928
dc.identifier.volume91en_US
dc.identifier.wosWOS:000701823500003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Zagreb, Facultty of Veterinary Medicine
dc.relation.ispartofVeterinarski Arhiv
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDog
dc.subjectContact Lens
dc.subjectLimbal Mesenchymal Stem Cells
dc.subjectKCS
dc.subjectTransplantation
dc.titleTransplantation of limbal derived MSCs grown on contact lenses in dogs with dry eye syndrome - can stem cells help
dc.typeArticle

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