The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis

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dc.authorid0000-0002-6865-6466
dc.contributor.authorTaşpınar, Mehmet
dc.contributor.authorBozo?lan, Alihan
dc.contributor.authorErtu?rul, Abdullah Seçkin
dc.contributor.authorElmas, L.
dc.date.accessioned2021-06-09T07:30:38Z
dc.date.available2021-06-09T07:30:38Z
dc.date.issued2020
dc.departmentTıp Fakültesi
dc.description*Taşpınar, Mehmet ( Aksaray, Yazar )
dc.description.abstractThis study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins (HBD) HBD-2, HBD-3, and calprotectin. Atherosclerosis is the most frequently observed cardiovascular disease. Dental and periodontal infections are known to provide a considerable basis for atheroma plaque formation. The study group consists of a total number of 40 subjects, with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic periodontitis. Clinical periodontal and blood parameters and HBD-2, HBD-3, and calprotectin biomarkers in the gingival crevicular fluid were measured. In both groups, following clinical periodontal treatment, a statistically significant decrease in white blood cells (WBC), low-density lipoproteins (LDL), fibrinogen, creatinine, and platelets (PLT), a statistically significant increase in high-density lipoproteins (HDL) in blood samples, statistically meaningful decrease in HBD-2, HBD-3, and calprotectin in the gingival crevicular fluid were achieved. Blood values and HBD-2, HBD-3, calprotectin amounts in the gingival crevicular fluid were increased significantly in the test group compared to the control group. A positive correlation was observed between decreases in HBD-2, HBD-3, calprotectin, and clinical periodontal indices. Regression in systemic inflammation was observed after clinical periodontal treatment. It is concluded that nonsurgical periodontal treatment of chronic periodontitis positively affects atherosclerosis prognosis.
dc.identifier.doi10.32604/biocell.2020.011470
dc.identifier.endpage344en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage337en_US
dc.identifier.urihttps:/dx.doi.org/10.32604/biocell.2020.011470
dc.identifier.urihttps://hdl.handle.net/20.500.12451/8099
dc.identifier.volume44en_US
dc.identifier.wosWOS:000572676600008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTech Science Press
dc.relation.ispartofBiocell
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAtherosclerosis
dc.subjectCalprotectin
dc.subjectHBD-2
dc.subjectHBD-3
dc.subjectPeriodontal Diseases
dc.titleThe role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis
dc.typeArticle

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