Effect of serum netrin-1 levels on diagnosis and prognosis in patients admitted to the emergency service for acute coronary syndrome
| dc.contributor.author | Mutlu, Hüseyin | |
| dc.contributor.author | Akıllı, Nazire | |
| dc.contributor.author | Cander, Başar | |
| dc.contributor.author | Köylü, Öznur | |
| dc.contributor.author | Gül, Murat | |
| dc.contributor.author | Köylü, Ramazan | |
| dc.date.accessioned | 2021-06-29T10:15:45Z | |
| dc.date.available | 2021-06-29T10:15:45Z | |
| dc.date.issued | 2020 | |
| dc.department | Tıp Fakültesi | |
| dc.description | *Mutlu, Hüseyin ( Aksaray, Yazar ) *Gül, Murat ( Aksaray, Yazar ) | |
| dc.description.abstract | Background Netrin-1 is a recently discovered diagnostic biomarker that indicates atherosclerosis, angiogenesis, and ischemia-reperfusion damage. There arc no human studies about Netrin-1 in acute coronary syndrome (ACS). The purpose of the present study was to investigate Netrin-1 levels in the early diagnosis and successful reperfusion of ACS. Method The study was conducted with 188 patients diagnosed with ACS and 50 healthy subjects at the emergency unit in a prospective design. Blood samples were collected from the patient group at initial admission and after angiography. The control group consisted of healthy adult subjects without any disease. Netrin-1 levels were studied in both groups. Results The Netrin-1 levels of the patient group at the time of admission were found to be higher than of the control group (p<0.001). In the patient group, netrin-1 levels measured at initial admission (1.53 +/- 0.19) and after angiography (1.49 +/- 0.19) were determined to be statistically significant (p:0.049). In the patient group, where the Thrombolysis in Myocardial Infarction (TIMI) 3 flow was established after angiography, netrin-1 levels were detected to be low (p:0.039). Netrin-1 levels obtained at the time of admission were determined to be significantly different in the Global Registry of Acute Coronary Events (GRACE) moderate and high-risk groups in comparison to the low-risk group (p:0.017). Conclusion Netrin-1 was shown to increase in the early diagnosis of ACS and to decrease in patients for whom reperfusion was established after angiography. Therefore, Netrin-1 can be an important biomarker as an indicator of diagnosis and successful reperfusion in ACS. | |
| dc.identifier.doi | 10.7759/cureus.7741 | |
| dc.identifier.endpage | - | en_US |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.startpage | - | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.7759/cureus.7741 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/8221 | |
| dc.identifier.volume | 12 | en_US |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Cureus | |
| dc.relation.ispartof | Cureus | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Netrin-1 | |
| dc.subject | Acute Coronary Syndrome | |
| dc.subject | Reperfusion | |
| dc.title | Effect of serum netrin-1 levels on diagnosis and prognosis in patients admitted to the emergency service for acute coronary syndrome | |
| dc.type | Article |
