Therapeutic potentials of propolis and pollen on biochemical changes in reproductive function of L-NAME induced hypertensive male rats

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dc.contributor.authorGülhan, Mehmet Fuat
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:16:36Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:16:36Z
dc.date.issued2019
dc.departmentTeknik Bilimler Meslek Yüksekokulu
dc.description.abstractBackground: Hypertension is described as increased blood pressure based on changed hemodynamics and associated with an increased oxidative damage to reproductive function. This work is to determine therapeutic and protective effects of apitherapy products (propolis and pollen) on reproductive functions of L-NAME-induced hypertensive male rats.Methods: Experimental animals were indiscriminately separated into four groups of seven rats in each group: (I) Control, (II) L-NAME, (III) L-NAME+propolis and (IV) L-NAME+pollen. At the end of the experimental applications, the rats were decapitated by anesthesia and biochemical analyzes were performed on the removed testicular tissues.Results: The levels of TOS, NF-B and MDA in the L-NAME group compared to control have increased (p<0.05). The levels of these parameters in L-NAME+propolis and L-NAME+pollen groups compared to the L-NAME group have decreased (p<0.05). TAS levels, PON1 and CAT activities were significantly decreased in testis tissue samples in the L-NAME-induced group (p<0.05). However, these parameters were significantly lower in the L-NAME plus propolis and pollen groups (p<0.05) compared with rats administered L-NAME alone (p<0.05). NO level significantly reduced (p<0.05) in L-NAME group compared with control group. There was no statistically significant changes in the NO level of the L-NAME+propolis group compared with the L-NAME-treated group (p>0.05).Conclusion: It has been determined that ethanolic extracts of propolis and pollen, which are natural bee products in the regulation of rising blood pressure. Propolis or pollen is thought to help regulate reproductive function by inhibiting the functioning of inflammatory pathways leading to hypertension.
dc.description.sponsorshipOmer Halisdemir University (Turkey) Research Fund [BAP 2012/38]
dc.description.sponsorshipOmer Halisdemir University (Turkey) Research Fund (Project number: BAP 2012/38) is gratefully acknowledged for support of this work.
dc.identifier.doi10.1080/10641963.2018.1506470
dc.identifier.endpage298en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue3en_US
dc.identifier.pmid30118326
dc.identifier.scopusqualityQ2
dc.identifier.startpage292en_US
dc.identifier.urihttps://doi.org/10.1080/10641963.2018.1506470
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4622
dc.identifier.volume41en_US
dc.identifier.wosWOS:000461561400013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HYPERTENSION
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHypertension
dc.subjectTestis
dc.subjectPropolis
dc.subjectPollen
dc.subjectOxidative Stress
dc.subjectNitric Oxide
dc.subjectParaoxonase
dc.titleTherapeutic potentials of propolis and pollen on biochemical changes in reproductive function of L-NAME induced hypertensive male rats
dc.typeArticle

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