Solubility and chromatographic separation of 5-fluorouracil under subcritical water conditions

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dc.authoridAkay, Sema -- 0000-0001-8887-6653; Kayan, Berkant -- 0000-0002-9892-5284
dc.contributor.authorAkay, Sema
dc.contributor.authorKayan, Berkant
dc.contributor.authorYang, Yu
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:16Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:16Z
dc.date.issued2017
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractThe drug 5-fluorouracil is used to treat several cancers including colon, esophageal, stomach, pancreatic, breast, and cervical cancer. In this study, the solubility of 5-fluorouracil in subcritical water was determined at temperatures ranging from 298 to 473 K under a constant pressure of 5.1 MPa. Our results show that the solubility of 5-fluorouracil is enhanced more than 12 -fold by increasing the temperature from 298 to 473 K. A new approximation model was developed to predict the solubility of 5-fluorouracil in subcritical water. Our predicted solubility values are comparable with the experimental ones. The modified Apelblat equation also yields good agreement with experimental values. Since our solubility study reveals that 5-fluorouracil has adequate solubility in subcritical water, the separation of 5-fluorouradl was conducted using subcritical water chromatography (SBWC) with water only mobile phase. Good chromatographic separation of 5-fluorouracil was achieved at temperatures of 348 to 473 K.
dc.description.sponsorshipScientific Research Project Unit (BAP) of Aksaray University [2016/038]
dc.description.sponsorshipThe authors gratefully thank the Scientific Research Project Unit (BAP) of Aksaray University (2016/038) for the financial support of this work.
dc.identifier.doi10.1021/acs.jced.7b00015
dc.identifier.endpage1543en_US
dc.identifier.issn0021-9568
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage1538en_US
dc.identifier.urihttps://doi.org/10.1021/acs.jced.7b00015
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6012
dc.identifier.volume62en_US
dc.identifier.wosWOS:000399436000048
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.ispartofJournal of Chemical and Engineering Data
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.titleSolubility and chromatographic separation of 5-fluorouracil under subcritical water conditions
dc.typeArticle

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