Punica granatum ljuice attenuates experimental cerebral vasospasm in the rabbit subarachnoid hemorrhage model: A basilar artery morphometric study and apoptosis

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dc.contributor.authorGüvenç, Yahya
dc.contributor.authorDemirci, Adnan Yalçın
dc.contributor.authorBillur D.
dc.contributor.authorAydın, Sevim
dc.contributor.authorÖzeren, Ersin
dc.contributor.authorBayram, Pınar
dc.contributor.authorDilli, Alper
dc.contributor.authorGökçe, Emre Cemal
dc.contributor.authorYaman, Onur
dc.contributor.authorÇelik, Haydar
dc.contributor.authorKaratay, Mete
dc.contributor.authorAlagöz, Fatih
dc.contributor.authorKaptano?lu, Erkan
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:21:42Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:21:42Z
dc.date.issued2017
dc.departmentTıp Fakültesi
dc.descriptionPubMed ID: 27509316
dc.description.abstractBackground This study investigated the effect of Punica granatum L. (pomegranate) juice on the rabbit basilar artery in an experimental subarachnoid hemorrhage (SAH) model. Methods Eighteen adult male New Zealand white rabbits were randomly divided into three groups: a control group (n = 6), SAH group (n = 6), and SAH + treatment group (n = 6). Basilar artery diameter was measured with magnetic resonance angiography (MRA) in all groups at the beginning of the study. Experimental SAH was created by injecting autologous arterial blood into the cisterna magna. In the treatment group, the subjects were administered a daily dose of 30 ml/kg pomegranate juice via gastric gavage for 4 days after the SAH. The SAH group and SAH + treatment group underwent cerebral MRA after 72 hours. After a neurologic score assessment, all the animals were killed. The wall thickness and lumen area of the basilar artery were measured histometrically in all groups, and the apoptotic cell percentage in the artery was identified. The mean diameter of the basilar artery during MRA was measured. Results Pomegranate improved neurologic functions compared with the SAH group (p < 0.01). The mean basilar artery diameter on MRA in the SAH + treatment group was larger than in the SAH group and smaller than in the control group (p < 0.01 and p < 0.05, respectively). The mean vessel wall thickness value in the SAH + treatment group was lower than in the SAH group (p < 0.01), whereas there was no difference between the control and the SAH + treatment group (p > 0.05). The apoptotic cell rate in the SAH + treatment group was significantly lower than in the SAH group (p < 0.001). Evaluation of the basilar artery luminal area showed no difference between the three groups (p > 0.05). Discussion Pomegranate was shown to have a vasospasm- attenuating effect on the basilar artery in the rabbit SAH model for the first time in our study. © 2017 Georg Thieme Verlag KG Stuttgart.New York.
dc.identifier.doi10.1055/s-0036-1584906
dc.identifier.endpage131en_US
dc.identifier.issn2193-6315
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage124en_US
dc.identifier.urihttps://dx.doi.org/10.1055/s-0036-1584906
dc.identifier.urihttps://hdl.handle.net/20.500.12451/2307
dc.identifier.volume78en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag
dc.relation.ispartofJournal of Neurological Surgery, Part A: Central European Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPomegranate
dc.subjectRabbit
dc.subjectSubarachnoid Hemorrhage
dc.subjectTreatment
dc.subjectVasospasm
dc.titlePunica granatum ljuice attenuates experimental cerebral vasospasm in the rabbit subarachnoid hemorrhage model: A basilar artery morphometric study and apoptosis
dc.typeArticle

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